Levy Roger A, Dos Santos Flavia Cunha, de Jesús Guilherme R, de Jesús Nilson R
Department of Rheumatology, Universidade do Estado do Rio de Janeiro , Rio de Janeiro , Brazil.
Department of Obstetrics, Universidade do Estado do Rio de Janeiro , Rio de Janeiro , Brazil.
Front Immunol. 2015 May 7;6:205. doi: 10.3389/fimmu.2015.00205. eCollection 2015.
Antiphospholipid syndrome (APS) comprises of a wide spectrum of clinical and obstetric manifestations linked to the presence of antiphospholipid antibodies (aPL). APS was described in the context of lupus, and later as an isolated syndrome or primary APS. The presence of aPL, especially the lupus anticoagulant test, is associated with adverse pregnancy outcomes, such as fetal death, recurrent early miscarriages, pre-eclampsia, and placental insufficiency, but does not seem to influence infertility. High quality scientific data to support these associations, however, are lacking, and controversies arise about the definition of positive aPL (low vs medium-high titers) or even the definition of the adverse events. This review discusses APS classification criteria and the current debate about it.
抗磷脂综合征（APS）由一系列与抗磷脂抗体（aPL）存在相关的临床和产科表现组成。APS最初是在狼疮背景下被描述的，后来被视为一种孤立综合征或原发性APS。aPL的存在，尤其是狼疮抗凝物检测结果，与不良妊娠结局相关，如胎儿死亡、复发性早期流产、子痫前期和胎盘功能不全，但似乎不影响不孕。然而，缺乏高质量的科学数据来支持这些关联，并且对于aPL阳性的定义（低滴度与中高滴度）甚至不良事件的定义也存在争议。本综述讨论了APS的分类标准以及当前对此的争论。
