通过微小RNA调控肿瘤髓源性抑制细胞
Regulating Tumor Myeloid-Derived Suppressor Cells by MicroRNAs.
作者信息
Chen Siqi, Zhang Yi, Kuzel Timothy M, Zhang Bin
机构信息
Biotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China ; Robert H. Lurie Comprehensive Cancer Center, Department of Medicine-Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Biotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
出版信息
Cancer Cell Microenviron. 2015;2(1). doi: 10.14800/ccm.637.
Abstract
Myeloid-derived suppressor cells (MDSCs) are one of the major cell components responsible for cancer immune evasion. Studying mechanisms associated with the regulation of MDSCs is becoming appreciated as another way to manipulate immune responses. MicroRNAs (miRNAs) have been recognized as substances which may interact with MDSCs, and eight miRNAs including miR-17-5p, miR-20a, miR-223, miR-21, miR-155, miR-494, miR-690 and miR-101 are of particular interest regarding MDSC accumulation and function. We have reviewed the data supporting this activity of these entities.
摘要
髓源性抑制细胞（MDSCs）是导致癌症免疫逃逸的主要细胞成分之一。研究与MDSCs调节相关的机制正被视为操纵免疫反应的另一种方式。微小RNA（miRNAs）已被认为是可能与MDSCs相互作用的物质，包括miR-17-5p、miR-20a、miR-223、miR-21、miR-155、miR-494、miR-690和miR-101在内的8种miRNAs在MDSC积累和功能方面尤其受到关注。我们已经回顾了支持这些物质这一活性的数据。
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