Humphries Matthew P, Jordan V Craig, Speirs Valerie
Leeds Institute of Cancer and Pathology, University of Leeds, St James's University Hospital, Leeds, LS9 7TF, UK.
Department of Breast Medical Oncology and Molecular and Cellular Oncology, MD Anderson Cancer Center, Houston, TX, 77030, USA.
BMC Med. 2015 Jun 4;13:134. doi: 10.1186/s12916-015-0380-x.
While rare compared to female breast cancer the incidence of male breast cancer (MBC) has increased in the last few decades. Without comprehensive epidemiological studies, the explanation for the increased incidence of MBC can only be speculated. Nevertheless, one of the most worrying global public health issues is the exponential rise in the number of overweight and obese people, especially in the developed world. Although obesity is not considered an established risk factor for MBC, studies have shown increased incidence among obese individuals. With this observation in mind, this article highlights the correlation between the increased incidence of MBC and the current trends in obesity as a growing problem in the 21(st) century, including how this may impact treatment. With MBC becoming more prominent we put forward the notion that, not only is obesity a risk factor for MBC, but that increasing obesity trends are a contributing factor to its increased incidence.
与女性乳腺癌相比，男性乳腺癌（MBC）的发病率虽然较低，但在过去几十年中呈上升趋势。由于缺乏全面的流行病学研究，MBC发病率上升的原因只能靠推测。然而，全球最令人担忧的公共卫生问题之一是超重和肥胖人群数量呈指数级增长，尤其是在发达国家。虽然肥胖不被视为MBC的既定风险因素，但研究表明肥胖个体的发病率有所增加。基于这一观察结果，本文强调了MBC发病率上升与肥胖这一21世纪日益严重的问题的当前趋势之间的相关性，包括这可能如何影响治疗。随着MBC越来越突出，我们提出这样一种观点，即肥胖不仅是MBC的一个风险因素，而且肥胖趋势的增加是其发病率上升的一个促成因素。
