Li Yunhai, Huang Ying, Huang Hongbo, Wei Tingting, Zhang Aijie, Xing Lei, Yin Xuedong, Li Hongyuan, Ren Guosheng, Li Fan
Department of Breast and Thyroid Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Health Management Center, University-Town Hospital Affiliated to Chongqing Medical University, Chongqing, China.
EClinicalMedicine. 2024 Dec 27;80:103027. doi: 10.1016/j.eclinm.2024.103027. eCollection 2025 Feb.
Male breast cancer (MBC) is a rare malignancy that has been under-investigated, with limited global epidemiological research dedicated to it. A comprehensive estimate of the global, regional, and national burden of MBC is valuable for policy planning. This study aims to evaluate the burden of MBC across 204 countries and territories.
MBC data were collected from the 2021 Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study estimates spanning from 1990 to 2021. The global incidence, prevalence, deaths, and disability-adjusted life-years (DALYs) attributed to MBC, as well as corresponding age-standardized rates, were calculated. Temporal trends, projections of incidence and mortality to 2050, lifetime risk, and risk factors of MBC were also estimated according to regions and countries.
In 2021, there were 38,827 (95% uncertainty interval [UI], 24,650-47,846) new cases, 320,459 (95% UI, 220,533-384,317) prevalent cases, 13,274 (95% UI, 9074-16,240) deaths, and 380,917 (95% UI, 252,922-476,417) DALYs attributed to MBC worldwide, with the highest disease burden observed in the Eastern Sub-Saharan Africa region. From 1990 to 2021, the age-standardized incidence and mortality rates of MBC significantly increased, but they are projected to decrease over the next 30 years. High-middle Socio-demographic Index (SDI) quintile had the highest lifetime risk of developing MBC, while the low SDI quintile had the highest lifetime risk of dying from MBC. Dietary risk and alcohol use were identified as important risk factors for MBC deaths and DALYs globally.
The global burden of MBC significantly increased from 1990 to 2021, with notable geographic disparities. Efforts aimed at MBC prevention and control strategies should take into account the inequities in its global distribution.
This study was supported by the National Natural Science Foundation of China (grant numbers 82372996 and 82202913) and the Chongqing Natural Science Foundation (grant number CSTB2023NSCQ-MSX0480).
男性乳腺癌（MBC）是一种罕见的恶性肿瘤，研究较少，全球专门针对它的流行病学研究有限。全面评估全球、区域和国家层面的MBC负担对政策规划具有重要意义。本研究旨在评估204个国家和地区的MBC负担。
从2021年全球疾病、伤害及危险因素负担（GBD）研究中收集了1990年至2021年期间的MBC数据。计算了全球范围内归因于MBC的发病率、患病率、死亡人数和伤残调整生命年（DALY），以及相应的年龄标准化率。还根据地区和国家估计了时间趋势、到2050年的发病率和死亡率预测、终生风险以及MBC的危险因素。
2021年，全球范围内归因于MBC的新发病例有38,827例（95%不确定区间[UI]，24,650 - 47,846），现患病例320,459例（95% UI，220,533 - 384,317），死亡13,274例（95% UI，9074 - 16,240），DALY为380,917例（95% UI，252,922 - 476,417），其中撒哈拉以南非洲东部地区疾病负担最高。1990年至2021年，MBC的年龄标准化发病率和死亡率显著上升，但预计在未来30年内将下降。社会人口学指数（SDI）中高五分位数人群患MBC的终生风险最高，而低SDI五分位数人群死于MBC的终生风险最高。饮食风险和饮酒被确定为全球范围内MBC死亡和DALY的重要危险因素。
1990年至2021年，全球MBC负担显著增加，存在明显的地理差异。MBC防控策略应考虑其全球分布的不平等性。
本研究得到中国国家自然科学基金（项目编号82372996和82202913）以及重庆市自然科学基金（项目编号CSTB2023NSCQ-MSX0480）的支持。
