利用负载中间前体的介孔载体对I型胶原蛋白进行仿生纤维内矿化
Biomimetic Intrafibrillar Mineralization of Type I Collagen with Intermediate Precursors-loaded Mesoporous Carriers.
作者信息
Zhang Wei, Luo Xiao-juan, Niu Li-na, Yang Hong-ye, Yiu Cynthia K Y, Wang Tian-da, Zhou Li-qun, Mao Jing, Huang Cui, Pashley David H, Tay Franklin R
机构信息
Tongji Hospital, Huazhong University of Science and Technology, Wuhan, PR China.
State Key Laboratory of Military Stomatology, Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University, Xi'an, PR China.
出版信息
Sci Rep. 2015 Jun 8;5:11199. doi: 10.1038/srep11199.
Abstract
Limited continuous replenishment of the mineralization medium is a restriction for in-situ solution-based remineralization of hypomineralized body tissues. Here, we report a process that generated amine-functionalized mesoporous silica nanoparticles for sustained release of biomimetic analog-stabilized amorphous calcium phosphate precursors. Both two-dimensional and three-dimensional collagen models can be intrafibrillarly mineralized with these released fluidic intermediate precursors. This represents an important advance in the translation of biomineralization concepts into regimes for in-situ remineralization of bone and teeth.
摘要
矿化介质的有限连续补充是基于原位溶液的低矿化身体组织再矿化的一个限制因素。在此，我们报告了一种制备胺功能化介孔二氧化硅纳米颗粒的方法，用于仿生类似物稳定的无定形磷酸钙前体的持续释放。二维和三维胶原蛋白模型都可以用这些释放的流体中间前体进行原纤维内矿化。这代表了将生物矿化概念转化为骨和牙齿原位再矿化机制方面的一项重要进展。
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