Casarosa Simona, Bozzi Yuri, Conti Luciano
Center for Integrative Biology, Università degli Studi di Trento, Via Sommarive 9, Povo-Trento, 38123 Italy.
Mol Cell Ther. 2014 Oct 15;2:31. doi: 10.1186/2052-8426-2-31. eCollection 2014.
Neural stem cells (NSCs) offer a unique and powerful tool for basic research and regenerative medicine. However, the challenges that scientists face in the comprehension of the biology and physiological function of these cells are still many. Deciphering NSCs fundamental biological aspects represents indeed a crucial step to control NSCs fate and functional integration following transplantation, and is essential for a safe and appropriate use of NSCs in injury/disease conditions. In this review, we focus on the biological properties of NSCs and discuss how these cells may be exploited to provide effective therapies for neurological disorders. We also review and discuss ongoing NSC-based clinical trials for these diseases.
神经干细胞（NSCs）为基础研究和再生医学提供了一种独特而强大的工具。然而，科学家在理解这些细胞的生物学和生理功能方面仍然面临诸多挑战。解读神经干细胞的基本生物学特性确实是控制其移植后命运和功能整合的关键一步，对于在损伤/疾病情况下安全、适当地使用神经干细胞至关重要。在本综述中，我们聚焦于神经干细胞的生物学特性，并讨论如何利用这些细胞为神经系统疾病提供有效的治疗方法。我们还回顾并讨论了正在进行的针对这些疾病的基于神经干细胞的临床试验。
