Cohen L A
Cancer Res. 1981 Sep;41(9 Pt 2):3808-10.
Evidence drawn from epidemiological and experimental studies suggests that dietary fat is an important determinant of breast cancer risk and, in addition, that dietary fat acts as a modulator rather than an initiator of breast carcinogenesis. At present, however, it is not known how dietary fat exerts its tumor-promoting effects. A variety of mechanisms, some involving direct action by fat at the target organ and others involving host-mediated responses, have been proposed. The present status of one of these, namely, a mechanism based on mediation by the endocrine system, and the hormone prolactin in particular, is described. Further studies in laboratory animals are required to determine the precise cellular and molecular events which underlie the fat effect.
来自流行病学和实验研究的证据表明，膳食脂肪是乳腺癌风险的重要决定因素，此外，膳食脂肪在乳腺癌发生过程中起调节作用而非引发作用。然而，目前尚不清楚膳食脂肪是如何发挥其促肿瘤作用的。人们提出了多种机制，其中一些涉及脂肪在靶器官的直接作用，另一些涉及宿主介导的反应。本文描述了其中一种机制的现状，即基于内分泌系统介导的机制，特别是激素催乳素。需要在实验动物中进行进一步研究，以确定脂肪效应背后的确切细胞和分子事件。
