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全球病毒网络:应对基孔肯雅热

The Global Virus Network: Challenging chikungunya.

作者信息

McSweegan Edward, Weaver Scott C, Lecuit Marc, Frieman Matthew, Morrison Thomas E, Hrynkow Sharon

机构信息

Global Virus Network, 801 W. Baltimore St., Baltimore, MD 21201, USA.

Institute for Human Infections and Immunity, Galveston National Laboratory Building, 301 University Blvd., Galveston, TX 77555-0610, USA.

出版信息

Antiviral Res. 2015 Aug;120:147-52. doi: 10.1016/j.antiviral.2015.06.003. Epub 2015 Jun 10.

DOI:10.1016/j.antiviral.2015.06.003
PMID:26071007
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4843800/
Abstract

The recent spread of chikungunya virus to the Western Hemisphere, together with the ongoing Ebola epidemic in West Africa, have highlighted the importance of international collaboration in the detection and management of disease outbreaks. In response to this need, the Global Virus Network (GVN) was formed in 2011. The GVN is a coalition of leading medical virologists in 34 affiliated laboratories in 24 countries, who collaborate to share their resources and expertise. The GVN supports research, promotes training for young scientists, serves as a technical resource for governments, businesses and international organizations, facilitates international scientific cooperation, and advocates for funding and evidence-based public policies. In response to the spread of chikungunya, the GVN formed a task force to identify research gaps and opportunities, including models of infection and disease, candidate vaccines and antivirals, epidemiology and vector control measures. Its members also serve as authoritative sources of information for the public, press, and policy-makers. This article forms part of a symposium in Antiviral Research on "Chikungunya discovers the New World".

摘要

基孔肯雅病毒最近在西半球的传播,以及西非持续的埃博拉疫情,凸显了国际合作在疾病暴发检测与管理中的重要性。为满足这一需求,全球病毒网络(GVN)于2011年成立。GVN是由24个国家34个附属实验室的顶尖医学病毒学家组成的联盟,他们合作共享资源与专业知识。GVN支持研究工作,推动对年轻科学家的培训,为政府、企业和国际组织提供技术资源,促进国际科学合作,并倡导资金投入和基于证据的公共政策。针对基孔肯雅病毒的传播,GVN成立了一个特别工作组,以确定研究空白和机会,包括感染与疾病模型、候选疫苗和抗病毒药物、流行病学以及病媒控制措施。其成员还为公众、媒体和政策制定者提供权威信息来源。本文是《抗病毒研究》中关于“基孔肯雅病毒发现新大陆”研讨会的一部分。

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本文引用的文献

1
Chikungunya: Evolutionary history and recent epidemic spread.基孔肯雅热:进化史与近期的流行传播。
Antiviral Res. 2015 Aug;120:32-9. doi: 10.1016/j.antiviral.2015.04.016. Epub 2015 May 12.
2
Reappearance of chikungunya, formerly called dengue, in the Americas.基孔肯雅热(曾被称为登革热)在美洲再度出现。
Emerg Infect Dis. 2015 Apr;21(4):557-61. doi: 10.3201/eid2104.141723.
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Immunogenicity, safety, and tolerability of a recombinant measles-virus-based chikungunya vaccine: a randomised, double-blind, placebo-controlled, active-comparator, first-in-man trial.
基孔肯雅热后关节炎:在孟加拉国一家三级护理医院进行的纵向研究。
Trop Med Health. 2022 Mar 8;50(1):21. doi: 10.1186/s41182-022-00412-9.
4
Cardiomyopathy and Death Following Chikungunya Infection: An Increasingly Common Outcome.基孔肯雅热感染后的心肌病与死亡:一种日益常见的结局
Trop Med Infect Dis. 2021 Jun 22;6(3):108. doi: 10.3390/tropicalmed6030108.
5
NAP1L1 and NAP1L4 Binding to Hypervariable Domain of Chikungunya Virus nsP3 Protein Is Bivalent and Requires Phosphorylation.NAP1L1 和 NAP1L4 与基孔肯雅病毒 nsP3 蛋白的高变区结合具有双重性,需要磷酸化。
J Virol. 2021 Jul 26;95(16):e0083621. doi: 10.1128/JVI.00836-21.
6
Reduced competence to arboviruses following the sustainable invasion of Wolbachia into native Aedes aegypti from Southeastern Brazil.沃尔巴克氏体可持续入侵巴西东南部本土埃及伊蚊后对虫媒病毒的适应能力降低。
Sci Rep. 2021 May 11;11(1):10039. doi: 10.1038/s41598-021-89409-8.
7
Epidemiological surveillance of chikungunya fever in Mexico since its introduction in 2014-2016 and identification of circulating genotypes.自 2014-2016 年引入以来墨西哥基孔肯雅热的流行病学监测以及循环基因型的鉴定。
Mol Biol Rep. 2021 Feb;48(2):1967-1975. doi: 10.1007/s11033-021-06151-0. Epub 2021 Feb 1.
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J Virol. 2020 Dec 9;95(1). doi: 10.1128/JVI.01672-20.
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Lack of nsP2-specific nuclear functions attenuates chikungunya virus replication both in vitro and in vivo.缺乏 nsP2 特异性核功能会减弱基孔肯雅病毒在体外和体内的复制。
Virology. 2019 Aug;534:14-24. doi: 10.1016/j.virol.2019.05.016. Epub 2019 May 28.
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Embryonic development and egg viability of wMel-infected Aedes aegypti.经 wMel 感染的埃及伊蚊的胚胎发育和卵活力。
Parasit Vectors. 2019 May 6;12(1):211. doi: 10.1186/s13071-019-3474-z.
基于重组麻疹病毒的基孔肯雅疫苗的免疫原性、安全性和耐受性:一项随机、双盲、安慰剂对照、活性对照、首次人体试验。
Lancet Infect Dis. 2015 May;15(5):519-27. doi: 10.1016/S1473-3099(15)70043-5. Epub 2015 Mar 2.
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Bindarit, an inhibitor of monocyte chemotactic protein synthesis, protects against bone loss induced by chikungunya virus infection.宾达利特,一种单核细胞趋化蛋白合成抑制剂,可预防基孔肯雅病毒感染引起的骨质流失。
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Molecules. 2014 Mar 24;19(3):3617-27. doi: 10.3390/molecules19033617.
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J Infect Dis. 2014 Jun 15;209(12):1882-90. doi: 10.1093/infdis/jiu114. Epub 2014 Feb 28.
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Chikungunya vaccine candidate is highly attenuated and protects nonhuman primates against telemetrically monitored disease following a single dose.基孔肯雅热候选疫苗高度减毒,可在单次接种后保护非人类灵长类动物免受遥测监测疾病的侵害。
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