a Programa de Pós-Graduação em Biologia Parasitária , Universidade Federal do Rio Grande do Norte , Natal , Brazil.
b Departmento de Ciências Biomédicas , Universidade do Estado do Rio Grande do Norte , Mossoró , Brazil.
Pathog Glob Health. 2018 Jun;112(4):182-194. doi: 10.1080/20477724.2018.1478777. Epub 2018 May 28.
Chikungunya fever is an emerging arbovirus infection, representing a serious public health problem. Its etiological agent is the Chikungunya virus (CHIKV). Transmission of this virus is mainly vector by mosquitoes of the genus Aedes, although transmission by blood transfusions and vertical transmission has also been reported. The disease presents high morbidity caused mainly by the arthralgia and arthritis generated. Cardiovascular and neurological manifestations have also been reported. The severity of the infection seems to be directly associated with the action of the virus, but also with the decompensation of preexisting comorbidities. Currently, there are no therapeutic products neither vaccines licensed to the infection CHIKV control, although several vaccine candidates are being evaluated and human polyvalent immunoglobulins anti-CHIKV had been tested. Antibodies can protect against the infection, but in sub-neutralizing concentrations can augment virus infection and exacerbate disease severity. So, the prevention still depends on the use of personal protection measures and vector control, which are only minimally effective.
基孔肯雅热是一种新发的虫媒病毒感染，是一个严重的公共卫生问题。其病原体是基孔肯雅病毒（CHIKV）。这种病毒主要通过伊蚊属的蚊子传播，但也有报道通过输血和垂直传播。这种疾病的发病率很高，主要是由关节痛和关节炎引起的。也有心血管和神经系统表现的报道。感染的严重程度似乎与病毒的作用直接相关，但也与原有合并症的失代偿有关。目前，还没有治疗产品也没有授权用于控制 CHIKV 感染的疫苗，尽管正在评估几种疫苗候选物，并且已经测试了抗 CHIKV 的人多价免疫球蛋白。抗体可以预防感染，但在亚中和浓度下可以增强病毒感染并加重疾病严重程度。因此，预防仍然取决于使用个人保护措施和病媒控制，而这些措施的效果非常有限。
