Sari Kamran, Ede Huseyin, Kapusuz Gencer Zeliha, Ozkiris Mahmut, Gocmen Ayse Yesim, Intepe Yavuz Selim
Otorhinolaryngology Department, Bozok University School of Medicine, 66200 Yozgat, Turkey.
Cardiology Department, Bozok University School of Medicine, 66200 Yozgat, Turkey.
Biomed Res Int. 2015;2015:807683. doi: 10.1155/2015/807683. Epub 2015 May 4.
Growth differentiation factor-(GDF-) is a prognostic biomarker in cardiovascular disorders (CVD). GDF-15 level was not studied in patients with obstructive sleep apnea syndrome (OSAS) before. In this study, we investigated serum GDF-15 levels in OSAS patients and compared them with healthy controls.
Polysomnographically, confirmed forty consecutive OSAS patients (20 men and 20 women) and forty consecutive healthy controls (23 men and 17 women) were enrolled in the study. The samples in each group had similar demographic characteristics and body mass index (BMI) values.
In the study, no significant correlation was found about GDF-15 levels of OSAS group and healthy controls. However, there was a significant statistical correlation between age and GDF-15 level. In correlation analysis, there was not any significant correlation between age and BMI.
Although various developing biomarkers have been studied in cardiovascular disorders, GDF-15 levels have attracted a widespread interest as predictors of cardiovascular risk. GDF-15 level has not been evaluated previously in patients with OSAS. A significant statistical correlation was found between age and GDF-15 level. To reveal close relation between OSAS and GDF-15, further studies are needed with combination of GDF-15 and other biomarkers in OSAS.
生长分化因子-（GDF-）是心血管疾病（CVD）的一种预后生物标志物。此前尚未对阻塞性睡眠呼吸暂停综合征（OSAS）患者的GDF-15水平进行研究。在本研究中，我们调查了OSAS患者的血清GDF-15水平，并将其与健康对照者进行比较。
通过多导睡眠图检查，连续纳入40例确诊的OSAS患者（20例男性和20例女性）以及40例连续的健康对照者（23例男性和17例女性）。每组样本的人口统计学特征和体重指数（BMI）值相似。
在本研究中，OSAS组和健康对照组的GDF-15水平未发现显著相关性。然而，年龄与GDF-15水平之间存在显著的统计学相关性。在相关性分析中，年龄与BMI之间没有任何显著相关性。
尽管在心血管疾病中已经研究了各种新兴的生物标志物，但GDF-15水平作为心血管风险的预测指标引起了广泛关注。此前尚未对OSAS患者的GDF-15水平进行评估。年龄与GDF-15水平之间存在显著的统计学相关性。为了揭示OSAS与GDF-15之间的密切关系，需要进一步结合GDF-15和OSAS中的其他生物标志物进行研究。
