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达特茅斯癌症纳米技术卓越中心:磁热疗

The Dartmouth Center for Cancer Nanotechnology Excellence: magnetic hyperthermia.

作者信息

Baker Ian, Fiering Steve N, Griswold Karl E, Hoopes P Jack, Kekalo Katerina, Ndong Christian, Paulsen Keith, Petryk Alicea A, Pogue Brian, Shubitidze Fridon, Weaver John

机构信息

Thayer School of Engineering, 14 Engineering Drive, Hanover, NH 03755, USA.

Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.

出版信息

Nanomedicine (Lond). 2015;10(11):1685-92. doi: 10.2217/nnm.15.64.

DOI:10.2217/nnm.15.64
PMID:26080693
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4493741/
Abstract

The Dartmouth Center for Cancer Nanotechnology Excellence - one of nine funded by the National Cancer Institute as part of the Alliance for Nanotechnology in Cancer - focuses on the use of magnetic nanoparticles for cancer diagnostics and hyperthermia therapy. It brings together a diverse team of engineers and biomedical researchers with expertise in nanomaterials, molecular targeting, advanced biomedical imaging and translational in vivo studies. The goal of successfully treating cancer is being approached by developing nanoparticles, conjugating them with Fabs, hyperthermia treatment, immunotherapy and sensing treatment response.

摘要

达特茅斯癌症纳米技术卓越中心——作为癌症纳米技术联盟的一部分,由美国国立癌症研究所资助的九个中心之一——专注于利用磁性纳米颗粒进行癌症诊断和热疗。该中心汇聚了一支多元化的工程师和生物医学研究人员团队,他们在纳米材料、分子靶向、先进生物医学成像和体内转化研究方面拥有专业知识。通过开发纳米颗粒、将它们与抗体片段结合、进行热疗、免疫疗法以及检测治疗反应,正在朝着成功治疗癌症的目标迈进。

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本文引用的文献

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Toward Localized Biomarker Concentration Measurements.迈向局部生物标志物浓度测量。
IEEE Trans Magn. 2015 Feb;51(2):1-4. doi: 10.1109/TMAG.2014.2324993.
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Antibody-mediated targeting of iron oxide nanoparticles to the folate receptor alpha increases tumor cell association in vitro and in vivo.抗体介导的氧化铁纳米颗粒靶向叶酸受体α可增强其在体外和体内与肿瘤细胞的结合。
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Magnetic nanoparticles with high specific absorption rate of electromagnetic energy at low field strength for hyperthermia therapy.
用于热疗的在低场强下具有高电磁能比吸收率的磁性纳米颗粒。
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