血脂谱测试值、2型糖尿病与牙周炎之间的关联。
Association of lipid profile test values, type-2 diabetes mellitus, and periodontitis.
作者信息
Kalsi D S, Chopra Jyoti, Sood Anchal
机构信息
Department of Periodontology, Baba Jaswant Singh Dental College, Ludhiana, Punjab, India.
Department of Biochemistry, Baba Jaswant Singh Dental College, Ludhiana, Punjab, India.
出版信息
Indian J Dent. 2015 Apr-Jun;6(2):81-4. doi: 10.4103/0975-962X.157270.
OBJECTIVE
A two-way relationship between diabetes and periodontal disease has been suggested; whereas obesity and impaired lipid profile are risk factors for type-2 diabetes mellitus. This study examined the relationship between lipid profile, oral glucose tolerance test (OGTT) with periodontal health/disease dependent variables in healthy, diabetic and impaired glucose tolerance subjects.
MATERIALS AND METHODS
120 patients were selected for the study and were determined to be periodontally healthy or diseased. All these patients underwent biochemical tests for OGTT and Lipid profile analysis and data was compared using Z-test.
RESULTS
The OGTT results deteriorated with deteriorating periodontal condition. A similar correlation was also observed between worsening lipid profile test values, OGTT score, and periodontal condition.
CONCLUSION
This study indicates that hyperlipidemia may be one of the factors associated with periodontitis and that periodontitis may itself lead to abnormal serum lipid levels. Therefore, in addition to effects on diabetes, periodontitis may contribute to elevated serum lipid levels and therefore potentially to systemic disease arising from chronic hyperlipidemia.
目的
糖尿病与牙周病之间已被提出存在双向关系；而肥胖和脂质谱受损是2型糖尿病的危险因素。本研究在健康、糖尿病和糖耐量受损的受试者中，检验了脂质谱、口服葡萄糖耐量试验（OGTT）与牙周健康/疾病相关变量之间的关系。
材料与方法
选择120例患者进行研究，并确定其牙周健康或患病。所有这些患者均接受了OGTT生化检测和脂质谱分析，并使用Z检验对数据进行比较。
结果
随着牙周状况恶化，OGTT结果变差。在脂质谱测试值恶化、OGTT评分和牙周状况之间也观察到类似的相关性。
结论
本研究表明，高脂血症可能是与牙周炎相关的因素之一，并且牙周炎本身可能导致血清脂质水平异常。因此，除了对糖尿病的影响外，牙周炎可能导致血清脂质水平升高，从而可能导致慢性高脂血症引发的全身性疾病。
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