Li W-Q, Zhang M, Danby F W, Han J, Qureshi A A
1] Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, RI 02903, USA [2] Department of Epidemiology, School of Public Health, Brown University, Providence, RI 02903, USA.
Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Br J Cancer. 2015 Jul 28;113(3):520-3. doi: 10.1038/bjc.2015.217. Epub 2015 Jun 23.
Rosacea is an inflammatory skin disease. We examined the association between personal history of rosacea and risk of incident cancers.
A total of 75 088 whites were included from the Nurses' Health Study II (1991-2011). Information on clinician-diagnosed rosacea and diagnosis year was collected in 2005. All cancers other than basal cell carcinoma (BCC) were confirmed.
During 1 447 205 person-years, we identified 5194 cases with internal malignancies and 5788 with skin cancers. We did not observe significant associations between personal history of rosacea and internal malignancies, except for thyroid cancer (hazard ratio (HR)=1.59, 95% confidence interval (CI)=1.07-2.36). Among skin cancers, personal history of rosacea was associated with an elevated risk of BCC (HR=1.50, 95% CI=1.35-1.67).
We suggest possible associations between personal history of rosacea and an increased risk of thyroid cancer and BCC. Further studies are warranted to replicate our findings and to explore the underlying mechanisms.
酒渣鼻是一种炎症性皮肤病。我们研究了酒渣鼻个人病史与癌症发病风险之间的关联。
护士健康研究II（1991 - 2011年）共纳入75088名白人。2005年收集了临床医生诊断的酒渣鼻信息及诊断年份。除基底细胞癌（BCC）外的所有癌症均得到确诊。
在1447205人年期间，我们确定了5194例内部恶性肿瘤病例和5788例皮肤癌病例。除甲状腺癌外，我们未观察到酒渣鼻个人病史与内部恶性肿瘤之间存在显著关联（风险比（HR）=1.59，95%置信区间（CI）=1.07 - 2.36）。在皮肤癌中，酒渣鼻个人病史与基底细胞癌风险升高相关（HR = 1.50，95% CI = 1.35 - 1.67）。
我们提示酒渣鼻个人病史与甲状腺癌和基底细胞癌风险增加之间可能存在关联。有必要进行进一步研究以重复我们的发现并探索潜在机制。
