School of Public Health, Institute for Chemical Carcinogenesis, Guangzhou Medical University, Guangzhou, China.
Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, Rhode Island; Department of Epidemiology, School of Public Health, Brown University, Providence, Rhode Island; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
J Am Acad Dermatol. 2017 Dec;77(6):1083-1087.e5. doi: 10.1016/j.jaad.2017.08.032. Epub 2017 Oct 21.
The relationship between obesity and rosacea is poorly understood.
To conduct the first cohort study to determine the association between obesity and risk for incident rosacea.
A total of 89,886 participants were included from the Nurses' Health Study II (1991-2005). Information on history of clinician-diagnosed rosacea and year of diagnosis was collected in 2005. Information on obesity was collected biennially during follow-up.
Over 14 years of follow-up, we identified 5249 incident cases of rosacea. The risk for rosacea was elevated for those with increased body mass index (BMI, P < .0001). Compared with a BMI of 21.0-22.9 kg/m, the hazard ratio of rosacea was 1.48 (95% confidence interval 1.33-1.64) for BMI ≥ 35.0. There was a trend toward an increased risk for rosacea among participants who had gained weight after age 18 years (P < .0001), with a hazard ratio of 1.04 (95% confidence interval 1.03-1.05) per 10-lb weight gain. We also observed significantly increased risk for rosacea associated with higher waist circumference and hip circumference (P < .0001), and the associations appeared to be independent of BMI.
This epidemiologic study did not explore underlying mechanisms of the association.
Measures of obesity were significantly associated with an increased risk for incident rosacea.
肥胖与酒渣鼻之间的关系尚未被充分了解。
开展首个队列研究，以确定肥胖与酒渣鼻发病风险之间的关联。
共纳入来自护士健康研究 II 期（1991-2005 年）的 89886 名参与者。于 2005 年收集参与者中曾由临床医生诊断为酒渣鼻的病史和发病年份的信息。在随访期间，每两年收集一次肥胖相关信息。
在超过 14 年的随访期间，我们共发现了 5249 例酒渣鼻新发病例。体重指数（BMI）较高者发生酒渣鼻的风险增加（P<0.0001）。与 BMI 为 21.0-22.9kg/m2相比，BMI≥35.0kg/m2的患者发生酒渣鼻的风险比为 1.48（95%置信区间 1.33-1.64）。在 18 岁以后体重增加的参与者中，酒渣鼻的发病风险呈上升趋势（P<0.0001），体重每增加 10 磅，风险比为 1.04（95%置信区间 1.03-1.05）。我们还观察到，与较高的腰围和臀围相比，酒渣鼻的发病风险显著增加（P<0.0001），且这种关联似乎独立于 BMI。
这项流行病学研究并未探讨关联的潜在机制。
肥胖指标与酒渣鼻发病风险显著相关。
