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基于金属的纳米颗粒与免疫系统：激活、炎症及潜在应用

Metal-Based Nanoparticles and the Immune System: Activation, Inflammation, and Potential Applications.

作者信息

Luo Yueh-Hsia, Chang Louis W, Lin Pinpin

机构信息

Division of Environmental Health and Occupational Medicine, National Health Research Institutes, 35 Keyan Road, Zhunan 35053, Miaoli County, Taiwan.

National Environmental Health Research Center, National Health Research Institutes, 35 Keyan Road, Zhunan 35053, Miaoli County, Taiwan.

出版信息

Biomed Res Int. 2015;2015:143720. doi: 10.1155/2015/143720. Epub 2015 Jun 1.

DOI:10.1155/2015/143720
PMID:26125021
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4466342/
Abstract

Nanomaterials, including metal-based nanoparticles, are used for various biological and medical applications. However, metals affect immune functions in many animal species including humans. Different physical and chemical properties induce different cellular responses, such as cellular uptake and intracellular biodistribution, leading to the different immune responses. The goals of this review are to summarize and discuss the innate and adaptive immune responses triggered by metal-based nanoparticles in a variety of immune system models.

摘要

包括金属基纳米颗粒在内的纳米材料被用于各种生物和医学应用。然而，金属会影响包括人类在内的许多动物物种的免疫功能。不同的物理和化学性质会引发不同的细胞反应，如细胞摄取和细胞内生物分布，从而导致不同的免疫反应。本综述的目的是总结和讨论在各种免疫系统模型中金属基纳米颗粒引发的固有免疫和适应性免疫反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18a0/4466342/9f2d7d1582a7/BMRI2015-143720.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18a0/4466342/9f2d7d1582a7/BMRI2015-143720.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18a0/4466342/9f2d7d1582a7/BMRI2015-143720.001.jpg

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本文引用的文献

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