Ruffell Tamatha, Azis Matilda, Hassanali Nedah, Ames Catherine, Browning Sophie, Bracegirdle Karen, Corrigall Richard, Laurens Kristin R, Hirsch Colette, Kuipers Elizabeth, Maddox Lucy, Jolley Suzanne
King's College London, Department of Psychology, Institute of Psychiatry, Psychology & Neuroscience, London, SE5 8AF, UK.
South London and Maudsley NHS Foundation Trust, London, UK.
Eur Child Adolesc Psychiatry. 2016 Mar;25(3):311-9. doi: 10.1007/s00787-015-0739-8. Epub 2015 Jul 7.
The psychosocial processes implicated in the development and maintenance of psychosis differ according to both the dimensional attributes (conviction, frequency, associated distress, adverse life impact) and the content or type (e.g. grandiosity, hallucinations, paranoia) of the psychotic symptoms experienced. This has informed the development of 'targeted' cognitive behavioural therapy for psychosis (CBTp): interventions focusing on specific psychological processes in the context of particular symptom presentations. In adults, larger effect sizes for change in primary outcomes are typically reported in trials of targeted interventions, compared to those for trials of generic CBTp approaches with multiple therapeutic foci. We set out to test the theoretical basis for developing targeted CBTp interventions for young people with distressing psychotic-like, or unusual, experiences (UEs). We investigated variations in the psychosocial processes previously associated with self-reported UE severity (reasoning, negative life events, emotional problems) according to UE dimensional attributes and content/type (using an established five-factor model) in a clinically referred sample of 72 young people aged 8-14 years. Regression analyses revealed associations of conviction and grandiosity with reasoning; of frequency, and hallucinations and paranoia, with negative life events; and of distress/adverse life impact, and paranoia and hallucinations, with emotional problems. We conclude that psychological targets for intervention differ according to particular characteristics of childhood UEs in much the same way as for psychotic symptoms in adults. The development of targeted interventions is therefore indicated, and tailoring therapy according to presentation should further improve clinical outcomes for these young people.
与精神病的发展和维持相关的社会心理过程,会因所经历的精神病症状的维度属性(坚信程度、频率、相关痛苦、对生活的负面影响)以及内容或类型(例如夸大观念、幻觉、偏执)的不同而有所差异。这为针对精神病的“靶向”认知行为疗法(CBTp)的发展提供了依据:干预措施聚焦于特定症状表现背景下的特定心理过程。在成年人中,与具有多个治疗重点的通用CBTp方法的试验相比,靶向干预试验中通常报告的主要结局变化的效应量更大。我们着手检验为有痛苦的类精神病性或异常体验(UEs)的年轻人开发靶向CBTp干预措施的理论基础。我们在一个由72名8至14岁临床转诊的年轻人样本中,根据UE的维度属性和内容/类型(使用已确立的五因素模型),调查了先前与自我报告的UE严重程度相关的社会心理过程的差异(推理、负面生活事件、情绪问题)。回归分析揭示了坚信程度和夸大观念与推理之间的关联;频率、幻觉和偏执与负面生活事件之间的关联;痛苦/对生活的负面影响、偏执和幻觉与情绪问题之间的关联。我们得出结论,干预的心理目标会因儿童期UE的特定特征而有所不同,这与成年人的精神病症状情况大致相同。因此,需要开发靶向干预措施,根据症状表现量身定制治疗方案应能进一步改善这些年轻人的临床结局。