Han Xia, Piao Mei Jing, Kim Ki Cheon, Madduma Hewage Susara Ruwan Kumara, Yoo Eun Sook, Koh Young Sang, Kang Hee Kyoung, Shin Jennifer H, Park Yeunsoo, Yoo Suk Jae, Chae Sungwook, Hyun Jin Won
School of Medicine, Jeju National University, Jeju 690-756.
Department of Mechanical Engineering & Graduate School of Medical Science and Engineering, KAIST, Daejeon 305-701.
Biomol Ther (Seoul). 2015 Jul;23(4):357-66. doi: 10.4062/biomolther.2015.005. Epub 2015 Jul 1.
Isorhamnetin (3-methylquercetin) is a flavonoid derived from the fruits of certain medicinal plants. This study investigated the photoprotective properties of isorhamnetin against cell damage and apoptosis resulting from excessive ultraviolet (UV) B exposure in human HaCaT keratinocytes. Isorhamnetin eliminated UVB-induced intracellular reactive oxygen species (ROS) and attenuated the oxidative modification of DNA, lipids, and proteins in response to UVB radiation. Moreover, isorhamnetin repressed UVB-facilitated programmed cell death in the keratinocytes, as evidenced by a reduction in apoptotic body formation, and nuclear fragmentation. Additionally, isorhamnetin suppressed the ability of UVB light to trigger mitochondrial dysfunction. Taken together, these results indicate that isorhamnetin has the potential to protect human keratinocytes against UVB-induced cell damage and death.
异鼠李素（3 - 甲基槲皮素）是一种从某些药用植物果实中提取的黄酮类化合物。本研究调查了异鼠李素对人HaCaT角质形成细胞因过度紫外线（UV）B照射而导致的细胞损伤和凋亡的光保护特性。异鼠李素消除了UVB诱导的细胞内活性氧（ROS），并减轻了DNA、脂质和蛋白质因UVB辐射而发生的氧化修饰。此外，异鼠李素抑制了角质形成细胞中UVB促进的程序性细胞死亡，这可通过凋亡小体形成和核碎片化减少得到证明。此外，异鼠李素抑制了UVB光引发线粒体功能障碍的能力。综上所述，这些结果表明异鼠李素具有保护人类角质形成细胞免受UVB诱导的细胞损伤和死亡的潜力。
