Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prolongación de Carpio y Plan de Ayala S/N.
Biosci Trends. 2015 Jun;9(3):149-59. doi: 10.5582/bst.2015.01035.
Autophagy is a highly conserved catabolic process for the degradation of cytosolic components including damaged organelles, protein aggregates, and intracellular bacteria through a lysosome-dependent pathway. Autophagy can be induced in response to stress conditions. Furthermore, autophagy has been described as involved in both innate and adaptive immune responses, and several studies have shown that certain microorganisms can be eliminated by the autophagic route in a process known as xenophagy. However, several pathogens have developed different strategies to evade or exploit autophagy to ensure their survival. Here, we review the role of autophagy in response to bacterial pathogens.
自噬是一种高度保守的溶酶体依赖途径的胞质成分降解过程，包括受损的细胞器、蛋白质聚集体和细胞内细菌。自噬可以响应应激条件而诱导。此外，自噬已被描述为参与先天和适应性免疫反应，并且几项研究表明，某些微生物可以通过自噬途径被消除，这一过程称为异噬作用。然而，几种病原体已经发展出不同的策略来逃避或利用自噬来确保它们的生存。在这里，我们综述了自噬在应对细菌病原体中的作用。
