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基于光动力疗法，开发一种含金丝桃素的新型制剂用于治疗皮肤利什曼病的体外和体内研究。

Development of a novel formulation with hypericin to treat cutaneous leishmaniasis based on photodynamic therapy in in vitro and in vivo studies.

作者信息

Montoya Andrés, Daza Alejandro, Muñoz Diana, Ríos Karina, Taylor Viviana, Cedeño David, Vélez Iván D, Echeverri Fernando, Robledo Sara M

机构信息

PECET-Medical Research institute, School of Medicine, University of Antioquia, Medellín, Colombia.

Department of Chemistry, Illinois State University, Normal, Illinois, USA.

出版信息

Antimicrob Agents Chemother. 2015 Sep;59(9):5804-13. doi: 10.1128/AAC.00545-15. Epub 2015 Jul 13.

DOI:10.1128/AAC.00545-15
PMID:26169411
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4538502/
Abstract

An evaluation of the leishmanicidal activity in vitro and in vivo of hypericin, an expanded-spectrum photosensitizer found in Hypericum perforatum, is presented. Hypericin was evaluated against intracellular amastigotes in vitro of Leishmania (Viannia) panamensis. A topical formulation containing 0.5% hypericin was developed and assayed in vivo in a hamster model of cutaneous leishmaniasis. Results demonstrate that hypericin induces a significant antiamastigote effect in vitro against L. panamensis by decreasing the number of parasites inside infected cells. The topical formulation of 0.5% hypericin allows healing of L. panamensis-induced lesions upon a topical application of 40 mg/day plus visible-light irradiation (5 J/cm(2), 15 min), twice a week for 3 weeks.

摘要

本文对贯叶连翘中发现的一种广谱光敏剂金丝桃素的体外和体内杀利什曼原虫活性进行了评估。对体外培养的巴拿马利什曼原虫（维氏亚属）细胞内无鞭毛体进行了金丝桃素评估。开发了一种含0.5%金丝桃素的局部用制剂，并在皮肤利什曼病仓鼠模型中进行了体内试验。结果表明，金丝桃素通过减少感染细胞内的寄生虫数量，在体外对巴拿马利什曼原虫具有显著的抗无鞭毛体作用。0.5%金丝桃素的局部用制剂在每天局部应用40 mg并加可见光照射（5 J/cm²，15分钟），每周两次，共3周的情况下，可使巴拿马利什曼原虫引起的损伤愈合。

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本文引用的文献

[1]
Cell accumulation and antileishmanial effect of exogenous and endogenous protoporphyrin IX after photodynamic treatment.

Biomedica. 2014

[2]
Probing the molecular mechanism of hypericin-induced parasite death provides insight into the role of spermidine beyond redox metabolism in Leishmania donovani.

Antimicrob Agents Chemother. 2015-1

[3]
Endothelial cell FGF signaling is required for injury response but not for vascular homeostasis.

Proc Natl Acad Sci U S A. 2014-9-16

[4]
Effect of vehicles and esterification on the penetration and distribution of hypericin in the skin of hairless mice.

Photodiagnosis Photodyn Ther. 2007-4-10

[5]
The Role of TGFβ Signaling in Wound Epithelialization.

Adv Wound Care (New Rochelle). 2014-7-1

[6]
Comparison of efficacy of topical phenytoin with hypericin in second-degree burn wound healing: an experimental study in rats.

Med Sci Monit Basic Res. 2014-4-3

[7]
Role of epidermal growth factor in healing of diabetic foot ulcers.

Indian J Surg. 2012-12

[8]
Cutaneous leishmaniasis: the efficacy of nonantimony treatment in the austere environment. Using cryotherapy, thermotherapy, and photodynamic therapy as an alternative method of treatment.

J Spec Oper Med. 2013

[9]
[PDT panoramic view. Principle, photosensitizers, light sources and validated indications in dermatology].

Ann Dermatol Venereol. 2013-11

[10]
12/15-lipoxygenase contributes to platelet-derived growth factor-induced activation of signal transducer and activator of transcription 3.

J Biol Chem. 2013-10-28

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