中性粒细胞与淋巴细胞比值是复发或转移性头颈部鳞状细胞癌患者的独立预后因素。
Neutrophil to lymphocyte ratio is an independent prognostic factor in patients with recurrent or metastatic head and neck squamous cell cancer.
作者信息
Salim Derya Kivrak, Mutlu Hasan, Eryilmaz Melek Karakurt, Salim Ozan, Musri Fatma Yalçin, Tural Deniz, Gündüz Şeyda, Coşkun Hasan Şenol
机构信息
Department of Medical Oncology, Akdeniz University Hospital, School of Medicine, Antalya 07059, Turkey.
Department of Hematology, Akdeniz University Hospital, School of Medicine, Antalya 07059, Turkey.
出版信息
Mol Clin Oncol. 2015 Jul;3(4):839-842. doi: 10.3892/mco.2015.557. Epub 2015 May 4.
Abstract
The neutrophil to lymphocyte ratio (NLR) has been widely investigated for its prognostic significance in cancer. In the present study, we aimed to determine whether NLR is a prognostic factor in patients with recurrent or metastatic head and neck squamous cell cancer (HNSCC). A total of 79 patients from the Akdeniz University database were retrospectively analyzed. The cut-off NLR was set at 2.93; patients with NLR >2.93 had a median overall survival (OS) of 12.1 months, whereas the median OS was not reached for patients with NLR ≤2.93 (P=0.027). On multivariate analysis, NLR and recurrence or metastatic site were found to be independent prognostic factors for OS (P=0.014 and P=0.002, respectively). Therefore, NLR was identified as an independent prognostic factor for OS in patients with recurrent or metastatic HNSCC.
摘要
中性粒细胞与淋巴细胞比值（NLR）在癌症中的预后意义已得到广泛研究。在本研究中，我们旨在确定NLR是否为复发或转移性头颈部鳞状细胞癌（HNSCC）患者的预后因素。对来自阿克德尼兹大学数据库的79例患者进行了回顾性分析。NLR的临界值设定为2.93；NLR>2.93的患者中位总生存期（OS）为12.1个月，而NLR≤2.93的患者中位OS未达到（P=0.027）。多因素分析显示，NLR和复发或转移部位是OS的独立预后因素（分别为P=0.014和P=0.002）。因此，NLR被确定为复发或转移性HNSCC患者OS的独立预后因素。
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