Kielsen Katrine, Shamim Zaiba, Ryder Lars P, Nielsen Flemming, Grandjean Philippe, Budtz-Jørgensen Esben, Heilmann Carsten
a Institute for Inflammation Research, Department of Rheumatology .
b Department of Pediatrics and Adolescent Medicine , and.
J Immunotoxicol. 2016;13(2):270-3. doi: 10.3109/1547691X.2015.1067259. Epub 2015 Jul 16.
Recent studies suggest that exposure to perfluorinated alkylate substances (PFASs) may induce immunosuppression in humans and animal models. In this exploratory study, 12 healthy adult volunteers were recruited. With each subject, serum-PFAS concentrations were measured and their antibody responses prospectively followed for 30 days after a booster vaccination with diphtheria and tetanus. The results indicated that serum-PFAS concentrations were positively correlated and positively associated with age and male sex. The specific antibody concentrations in serum were increased from Day 4 to Day 10 post-booster, after which a constant concentration was reached. Serum PFAS concentrations showed significant negative associations with the rate of increase in the antibody responses. Interestingly, this effect was particularly strong for the longer-chain PFASs. All significant associations remained significant after adjustment for sex and age. Although the study involved a small number of subjects, these findings of a PFAS-associated reduction of the early humoral immune response to booster vaccination in healthy adults supported previous findings of PFAS immunosuppression in larger cohorts. Furthermore, the results suggested that cellular mechanisms right after antigen exposure should be investigated more closely to identify possible mechanisms of immunosuppression from PFAS.
最近的研究表明，接触全氟烷基化物（PFASs）可能会在人类和动物模型中诱发免疫抑制。在这项探索性研究中，招募了12名健康成年志愿者。对每个受试者测量血清PFAS浓度，并在白喉和破伤风加强疫苗接种后对其抗体反应进行30天的前瞻性跟踪。结果表明，血清PFAS浓度与年龄和男性呈正相关。血清中特异性抗体浓度在加强疫苗接种后第4天至第10天升高，之后达到恒定浓度。血清PFAS浓度与抗体反应的增加速率呈显著负相关。有趣的是，这种效应在长链PFASs中尤为明显。在对性别和年龄进行调整后，所有显著关联仍然显著。尽管该研究涉及的受试者数量较少，但这些关于PFAS与健康成年人加强疫苗接种后早期体液免疫反应降低相关的发现支持了之前在更大队列中关于PFAS免疫抑制的发现。此外，结果表明应更密切地研究抗原暴露后立即出现的细胞机制，以确定PFAS免疫抑制的可能机制。
