Spielberg Jeffrey M, Miller Gregory A, Heller Wendy, Banich Marie T
Neuroimaging Research for Veterans Center, Veterans Affairs Boston Healthcare System, Boston, MA 02130; Department of Psychiatry, Boston University School of Medicine, Boston, MA 02130;
Departments of Psychology and Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095; Department of Psychology, University of Illinois at Urbana-Champaign, Champaign, IL 61820;
Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):10020-5. doi: 10.1073/pnas.1500048112. Epub 2015 Jul 27.
The ability to inhibit distracting stimuli from interfering with goal-directed behavior is crucial for success in most spheres of life. Despite an abundance of studies examining regional brain activation, knowledge of the brain networks involved in inhibitory control remains quite limited. To address this critical gap, we applied graph theory tools to functional magnetic resonance imaging data collected while a large sample of adults (n = 101) performed a color-word Stroop task. Higher demand for inhibitory control was associated with restructuring of the global network into a configuration that was more optimized for specialized processing (functional segregation), more efficient at communicating the output of such processing across the network (functional integration), and more resilient to potential interruption (resilience). In addition, there were regional changes with right inferior frontal sulcus and right anterior insula occupying more central positions as network hubs, and dorsal anterior cingulate cortex becoming more tightly coupled with its regional subnetwork. Given the crucial role of inhibitory control in goal-directed behavior, present findings identifying functional network organization supporting inhibitory control have the potential to provide additional insights into how inhibitory control may break down in a wide variety of individuals with neurological or psychiatric difficulties.
抑制干扰性刺激以防止其妨碍目标导向行为的能力，对于在生活的大多数领域取得成功至关重要。尽管有大量研究考察了大脑区域激活情况，但对于参与抑制控制的脑网络的了解仍然相当有限。为了填补这一关键空白，我们将图论工具应用于一大群成年人（n = 101）执行色词Stroop任务时收集的功能磁共振成像数据。对抑制控制的更高需求与全局网络重组为一种配置有关，这种配置更优化用于专门处理（功能分离），在跨网络传达此类处理的输出方面更高效（功能整合），并且对潜在干扰更具弹性（弹性）。此外，存在区域变化，右下额沟和右前岛叶作为网络枢纽占据更中心的位置，背侧前扣带回皮层与其区域子网的耦合变得更紧密。鉴于抑制控制在目标导向行为中的关键作用，目前确定支持抑制控制的功能网络组织的研究结果，有可能为抑制控制在各种有神经或精神障碍的个体中可能如何瓦解提供更多见解。
