• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

2型糖尿病患者中性粒细胞/淋巴细胞比值与多层螺旋计算机断层扫描检测的阻塞性冠状动脉疾病及冠状动脉钙化评分的相关性

Association of neutrophil/lymphocyte ratio with obstructive coronary artery disease and coronary artery calcium score detected by multislice computed tomography in type 2 diabetes mellitus patients.

作者信息

Aygün Fatih, Efe Duran

机构信息

Department of Cardiovascular Surgery, Konya Medical and Research Center, Başkent University, Konya, Turkey.

Department of Radiology, Faculty of Medicine, Mevlana University, Konya, Turkey.

出版信息

Patient Prefer Adherence. 2015 Jul 17;9:1023-31. doi: 10.2147/PPA.S85577. eCollection 2015.

DOI:10.2147/PPA.S85577
PMID:26229449
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4514314/
Abstract

OBJECTIVE

The aim of the present study was to investigate the association of neutrophil/lymphocyte ratio (NLR) with coronary artery calcium score (CACS) and obstructive coronary artery disease (CAD) detected by multislice computed tomography (MSCT) angiography in type 2 diabetes mellitus (T2DM) patients.

METHODS

Two hundred and ninety-two T2DM patients, who were either asymptomatic or symptomatic (but noncharacteristic) for coronary artery disease (CAD) and underwent MSCT angiography in our clinic between May 2009 and June 2014, were enrolled. All patients were divided into two groups according to their mean NLR values. Patients with NLR ≤2.05 were assigned to Group 1 and patients with NLR >2.05 were assigned to Group 2. The association of NLR with CACS and obstructive CAD, which were detected by MSCT angiography, was investigated in T2DM patients.

RESULTS

According to the Agatston scoring method, the mean CACS was 129.5±209.8 Au in Group 1 and 290.3±399.6 Au in Group 2 (P<0.001). Obstructive CAD was detected in 40 (26.8%) patients in Group 1 and in 56 (39.2%) patients in Group 2 (P<0.05, P<0.021).

CONCLUSION

The rate of obstructive CAD was significantly higher in the T2DM patients with NLR >2.05 than that in the T2DM patients with NLR ≤2.05. In addition, the CACS was also significantly higher in the T2DM patients with NLR >2.05 than that in the T2DM patients with NLR ≤2.05.

摘要

目的

本研究旨在探讨2型糖尿病（T2DM）患者中性粒细胞/淋巴细胞比值（NLR）与多层螺旋计算机断层扫描（MSCT）血管造影检测的冠状动脉钙化积分（CACS）及阻塞性冠状动脉疾病（CAD）之间的关联。

方法

纳入292例T2DM患者，这些患者无症状或有冠状动脉疾病（CAD）的症状（但不典型），于2009年5月至2014年6月在我院接受MSCT血管造影检查。所有患者根据其平均NLR值分为两组。NLR≤2.05的患者被分配到第1组，NLR>2.05的患者被分配到第2组。在T2DM患者中研究NLR与MSCT血管造影检测的CACS及阻塞性CAD之间的关联。

结果

根据阿加斯顿评分法，第1组的平均CACS为129.5±209.8 Au，第2组为290.3±399.6 Au（P<0.001）。第1组有40例（26.8%）患者检测到阻塞性CAD，第2组有56例（39.2%）患者检测到阻塞性CAD（P<0.05，P<0.021）。

结论

NLR>2.05的T2DM患者阻塞性CAD的发生率显著高于NLR≤2.05的T2DM患者。此外，NLR>2.05的T2DM患者的CACS也显著高于NLR≤2.05的T2DM患者。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b31/4514314/ed6ab3f4f758/ppa-9-1023Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b31/4514314/3e1b2eb99a5c/ppa-9-1023Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b31/4514314/2dad2ede1731/ppa-9-1023Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b31/4514314/a867ca216a85/ppa-9-1023Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b31/4514314/0623f85492ea/ppa-9-1023Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b31/4514314/ed6ab3f4f758/ppa-9-1023Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b31/4514314/3e1b2eb99a5c/ppa-9-1023Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b31/4514314/2dad2ede1731/ppa-9-1023Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b31/4514314/a867ca216a85/ppa-9-1023Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b31/4514314/0623f85492ea/ppa-9-1023Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b31/4514314/ed6ab3f4f758/ppa-9-1023Fig5.jpg

相似文献

1
Association of neutrophil/lymphocyte ratio with obstructive coronary artery disease and coronary artery calcium score detected by multislice computed tomography in type 2 diabetes mellitus patients.2型糖尿病患者中性粒细胞/淋巴细胞比值与多层螺旋计算机断层扫描检测的阻塞性冠状动脉疾病及冠状动脉钙化评分的相关性
Patient Prefer Adherence. 2015 Jul 17;9:1023-31. doi: 10.2147/PPA.S85577. eCollection 2015.
2
The significance of coronary artery calcium score as a predictor of coronary artery stenosis in individuals referred for CT angiography.冠状动脉钙化积分作为接受CT血管造影检查个体冠状动脉狭窄预测指标的意义。
J Cardiovasc Thorac Res. 2020;12(3):203-208. doi: 10.34172/jcvtr.2020.34. Epub 2020 Sep 3.
3
The Combined Impact of Neutrophil-to-Lymphocyte Ratio and Type 2 Diabetic Mellitus on Significant Coronary Artery Disease and Carotid Artery Atherosclerosis.中性粒细胞与淋巴细胞比值和2型糖尿病对严重冠状动脉疾病和颈动脉粥样硬化的联合影响
J Cardiovasc Ultrasound. 2016 Jun;24(2):115-22. doi: 10.4250/jcu.2016.24.2.115. Epub 2016 Jun 22.
4
Deep learning-based coronary artery calcium score to predict coronary artery disease in type 2 diabetes mellitus.基于深度学习的冠状动脉钙化评分预测2型糖尿病患者的冠状动脉疾病
Heliyon. 2024 Mar 10;10(6):e27937. doi: 10.1016/j.heliyon.2024.e27937. eCollection 2024 Mar 30.
5
Prevalence of coronary artery disease in low to moderate-risk asymptomatic women: a multislice computed tomography study.低至中度风险无症状女性冠状动脉疾病的患病率：一项多层计算机断层扫描研究
Turk Kardiyol Dern Ars. 2008 Oct;36(7):439-45.
6
Prevalence of coronary artery disease and plaque morphology assessed by multi-slice computed tomography coronary angiography and calcium scoring in asymptomatic patients with type 2 diabetes.通过多层计算机断层扫描冠状动脉造影和钙化积分评估无症状2型糖尿病患者的冠状动脉疾病患病率及斑块形态
Heart. 2008 Mar;94(3):290-5. doi: 10.1136/hrt.2007.121921. Epub 2007 Jul 23.
7
Calcium score of coronary artery stratifies the risk of obstructive coronary artery diseases.冠状动脉钙化评分可对阻塞性冠状动脉疾病的风险进行分层。
Clin Ter. 2013;164(5):391-5. doi: 10.7417/CT.2013.1601.
8
Predictive Value of Non-high-Density Lipoprotein Cholesterol and Neutrophil-Lymphocyte Ratio for Coronary Artery Vulnerable Plaques in Type 2 Diabetes Mellitus.非高密度脂蛋白胆固醇和中性粒细胞与淋巴细胞比值对2型糖尿病患者冠状动脉易损斑块的预测价值
Front Cardiovasc Med. 2022 Jun 20;9:927768. doi: 10.3389/fcvm.2022.927768. eCollection 2022.
9
Long-term prognostic value of coronary computed tomography angiography for asymptomatic patients with CAD in type 2 diabetes mellitus.冠状动脉计算机断层扫描血管造影对2型糖尿病无症状冠心病患者的长期预后价值
Exp Ther Med. 2019 Jul;18(1):747-754. doi: 10.3892/etm.2019.7593. Epub 2019 May 20.
10
The Atherosclerosis Profile by Coronary Computed Tomography Angiography (CTA) in Symptomatic Patients with Coronary Artery Calcium Score Zero.有症状的冠状动脉钙化积分为零的患者经冠状动脉计算机断层扫描血管造影（CTA）检测的动脉粥样硬化情况
Diagnostics (Basel). 2022 Aug 24;12(9):2042. doi: 10.3390/diagnostics12092042.

引用本文的文献

1
Comparison of the prognostic value of complete blood count-derived inflammatory markers for long-term outcomes in ST-segment elevation myocardial infarction.全血细胞计数衍生的炎症标志物对ST段抬高型心肌梗死长期预后价值的比较
Intern Emerg Med. 2025 Jun 16. doi: 10.1007/s11739-025-04018-x.
2
THE CLINICAL SIGNIFICANCE OF COMPLETE BLOOD COUNT, NEUTROPHIL-TO-LYMPHOCYTE RATIO, AND MONOCYTE-TO-LYMPHOCYTE RATIO IN GESTATIONAL DIABETES MELLITUS.全血细胞计数、中性粒细胞与淋巴细胞比值及单核细胞与淋巴细胞比值在妊娠期糖尿病中的临床意义
Acta Endocrinol (Buchar). 2023 Oct-Dec;19(4):441-446. doi: 10.4183/aeb.2023.441. Epub 2024 Jun 24.
3

本文引用的文献

1
Disease complexity in acute coronary syndrome is related to the patient's immunological status.急性冠状动脉综合征中的疾病复杂性与患者的免疫状态有关。
Int J Cardiol. 2015;189:115-23. doi: 10.1016/j.ijcard.2015.04.063. Epub 2015 Apr 10.
2
Neutrophil-to-lymphocyte ratio predicts hemodynamic significance of coronary artery stenosis.中性粒细胞与淋巴细胞比值可预测冠状动脉狭窄的血流动力学意义。
Anatol J Cardiol. 2015;15(12):1002-7. doi: 10.5152/akd.2015.5909. Epub 2015 Apr 2.
3
Neutrophil to Lymphocyte Ratio and the Extent of Coronary Artery Disease: Results From a Large Cohort Study.
Importance of so called "novel cardiovascular risk factors" in severity of coronary artery calcification; how serious they should be taken: a systematic review and metaanalysis.
所谓“新型心血管危险因素”在冠状动脉钙化严重程度中的重要性；应该如何认真对待它们：系统评价和荟萃分析。
Arch Cardiol Mex. 2023 Apr 5;93(2):212-222. doi: 10.24875/ACM.210004061.
4
High neutrophil to lymphocyte ratio with type 2 diabetes mellitus predicts poor prognosis in patients undergoing percutaneous coronary intervention: a large-scale cohort study.高中性粒细胞与淋巴细胞比值与 2 型糖尿病患者经皮冠状动脉介入治疗预后不良相关：一项大规模队列研究。
Cardiovasc Diabetol. 2022 Aug 13;21(1):156. doi: 10.1186/s12933-022-01583-9.
5
Neutrophil Lymphocyte Ratio and Cardiovascular Disease Risk: A Systematic Review and Meta-Analysis.中性粒细胞与淋巴细胞比值与心血管疾病风险：系统评价与荟萃分析。
Biomed Res Int. 2018 Nov 11;2018:2703518. doi: 10.1155/2018/2703518. eCollection 2018.
6
Use of Readily Accessible Inflammatory Markers to Predict Diabetic Kidney Disease.使用易于获取的炎症标志物预测糖尿病肾病
Front Endocrinol (Lausanne). 2018 May 22;9:225. doi: 10.3389/fendo.2018.00225. eCollection 2018.
7
The Neutrophil-Lymphocyte Ratio Is Associated with Coronary Artery Calcification in Asymptomatic Korean Males: A Cross-Sectional Study.中性粒细胞与淋巴细胞比值与无症状韩国男性冠状动脉钙化相关：一项横断面研究
Biomed Res Int. 2017;2017:1989417. doi: 10.1155/2017/1989417. Epub 2017 Feb 9.
8
Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios: are they useful for predicting gestational diabetes mellitus during pregnancy?中性粒细胞与淋巴细胞比值及血小板与淋巴细胞比值：它们对预测妊娠期糖尿病有用吗？
Ther Clin Risk Manag. 2016 Apr 26;12:657-65. doi: 10.2147/TCRM.S104247. eCollection 2016.
中性粒细胞与淋巴细胞比值和冠状动脉疾病程度：一项大型队列研究的结果
Angiology. 2016 Jan;67(1):75-82. doi: 10.1177/0003319715577529. Epub 2015 Mar 29.
4
Neutrophil to lymphocyte ratio predicts SYNTAX score in patients with non-ST segment elevation myocardial infarction.中性粒细胞与淋巴细胞比值可预测非ST段抬高型心肌梗死患者的SYNTAX评分。
Int Heart J. 2015;56(1):18-21. doi: 10.1536/ihj.14-175. Epub 2014 Dec 24.
5
Serum neutrophil gelatinase-associated lipocalin levels and aortic stiffness in noncritical coronary artery disease.非临界冠状动脉疾病患者血清中性粒细胞明胶酶相关脂质运载蛋白水平与主动脉僵硬度
Cardiorenal Med. 2014 Dec;4(3-4):147-54. doi: 10.1159/000365200.
6
The Relation Between Atherosclerosis and the Neutrophil-Lymphocyte Ratio.动脉粥样硬化与中性粒细胞-淋巴细胞比值之间的关系
Clin Appl Thromb Hemost. 2016 Jul;22(5):405-11. doi: 10.1177/1076029615569568. Epub 2015 Feb 9.
7
Diagnosis and classification of diabetes mellitus.糖尿病的诊断与分类
Diabetes Care. 2014 Jan;37 Suppl 1:S81-90. doi: 10.2337/dc14-S081.
8
ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD: the Task Force on diabetes, pre-diabetes, and cardiovascular diseases of the European Society of Cardiology (ESC) and developed in collaboration with the European Association for the Study of Diabetes (EASD).与欧洲糖尿病研究协会（EASD）合作制定的欧洲心脏病学会（ESC）糖尿病、糖尿病前期和心血管疾病指南：欧洲心脏病学会（ESC）糖尿病、糖尿病前期和心血管疾病特别工作组与欧洲糖尿病研究协会（EASD）合作制定。
Eur Heart J. 2013 Oct;34(39):3035-87. doi: 10.1093/eurheartj/eht108. Epub 2013 Aug 30.
9
Insulin resistance and heart failure: molecular mechanisms.胰岛素抵抗与心力衰竭：分子机制。
Heart Fail Clin. 2012 Oct;8(4):609-17. doi: 10.1016/j.hfc.2012.06.005. Epub 2012 Aug 9.
10
Neutrophil-lymphocyte ratio as a predictor of major adverse cardiac events among diabetic population: a 4-year follow-up study.中性粒细胞与淋巴细胞比值对糖尿病患者主要不良心脏事件的预测作用：一项 4 年随访研究。
Angiology. 2013 Aug;64(6):456-65. doi: 10.1177/0003319712455216. Epub 2012 Aug 16.