基于益生菌的针对多种胃肠道疾病的治疗和预防策略。
Probiotic-based strategies for therapeutic and prophylactic use against multiple gastrointestinal diseases.
作者信息
Varankovich Natallia V, Nickerson Michael T, Korber Darren R
机构信息
Department of Food and Bioproduct Sciences, University of Saskatchewan, Saskatoon SK, Canada.
出版信息
Front Microbiol. 2015 Jul 14;6:685. doi: 10.3389/fmicb.2015.00685. eCollection 2015.
Abstract
Probiotic bacteria offer a number of potential health benefits when administered in sufficient amounts that in part include reducing the number of harmful organisms in the intestine, producing antimicrobial substances and stimulating the body's immune response. However, precisely elucidating the probiotic effect of a specific bacterium has been challenging due to the complexity of the gut's microbial ecosystem and a lack of definitive means for its characterization. This review provides an overview of widely used and recently described probiotics, their impact on the human's gut microflora as a preventative treatment of disease, human/animal models being used to help show efficacy, and discusses the potential use of probiotics in gastrointestinal diseases associated with antibiotic administration.
摘要
当摄入足够量时，益生菌具有许多潜在的健康益处，部分益处包括减少肠道中有害微生物的数量、产生抗菌物质以及刺激身体的免疫反应。然而，由于肠道微生物生态系统的复杂性以及缺乏明确的表征方法，精确阐明特定细菌的益生菌作用一直具有挑战性。本文综述了广泛使用的和最近描述的益生菌、它们作为疾病预防性治疗对人类肠道微生物群的影响、用于帮助证明疗效的人类/动物模型，并讨论了益生菌在与抗生素使用相关的胃肠道疾病中的潜在用途。
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