Togao Osamu, Hiwatashi Akio, Yamashita Koji, Kikuchi Kazufumi, Mizoguchi Masahiro, Yoshimoto Koji, Suzuki Satoshi O, Iwaki Toru, Obara Makoto, Van Cauteren Marc, Honda Hiroshi
Department of Clinical Radiology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan (O.T., A.H., K.Y., K.K., H.H.); Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (M.M., K.Y.); Department of Neuropathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (S.O.S., T.I.); Philips Electronics Japan, Tokyo, Japan (M.O., M.V.C.).
Neuro Oncol. 2016 Jan;18(1):132-41. doi: 10.1093/neuonc/nov147. Epub 2015 Aug 4.
Our aim was to assess the diagnostic performance of intravoxel incoherent motion (IVIM) MR imaging for differentiating high-grade gliomas (HGGs) from low-grade gliomas (LGGs).
Forty-five patients with diffuse glioma (age 50.9 ± 20.4 y; 26 males, 19 females) were assessed with IVIM imaging using 13 b-values (0-1000 s/mm(2)) at 3T. The perfusion fraction (f), true diffusion coefficient (D), and pseudo-diffusion coefficient (D*) were calculated by fitting the bi-exponential model. The apparent diffusion coefficient (ADC) was obtained with 2 b-values (0 and 1000 s/mm(2)). Relative cerebral blood volume was measured by the dynamic susceptibility contrast method. Two observers independently measured D, ADC, D*, and f, and these measurements were compared between the LGG group (n = 16) and the HGG group (n = 29).
Both D (1.26 ± 0.37 mm(2)/s in LGG, 0.94 ± 0.19 mm(2)/s in HGG; P < .001) and ADC (1.28 ± 0.35 mm(2)/s in LGG, 1.03 ± 0.19 mm(2)/s in HGG; P < .01) were lower in the HGG group. D was lower than ADC in the LGG (P < .05) and HGG groups (P < .0001). D* was not different between the groups. The f-values were significantly larger in HGG (17.5 ± 6.3%) than in LGG (5.8 ± 3.8%; P < .0001) and correlated with relative cerebral blood volume (r = 0.85; P < .0001). Receiver operating characteristic analyses showed areas under curve of 0.95 with f, 0.78 with D, 0.73 with ADC, and 0.60 with D*.
IVIM imaging is useful in differentiating HGGs from LGGs.
我们的目的是评估体素内不相干运动（IVIM）磁共振成像在鉴别高级别胶质瘤（HGG）与低级别胶质瘤（LGG）方面的诊断性能。
对45例弥漫性胶质瘤患者（年龄50.9±20.4岁；男性26例，女性19例）在3T条件下使用13个b值（0 - 1000 s/mm²）进行IVIM成像评估。通过拟合双指数模型计算灌注分数（f）、真实扩散系数（D）和伪扩散系数（D*）。使用2个b值（0和1000 s/mm²）获得表观扩散系数（ADC）。通过动态磁敏感对比法测量相对脑血容量。两名观察者独立测量D、ADC、D*和f，并对LGG组（n = 16）和HGG组（n = 29）之间的这些测量值进行比较。
HGG组的D（LGG组为1.26±0.37 mm²/s，HGG组为0.94±0.19 mm²/s；P <.001）和ADC（LGG组为1.28±0.35 mm²/s，HGG组为1.03±0.19 mm²/s；P <.01）均较低。在LGG组（P <.05）和HGG组（P <.0001）中，D均低于ADC。两组之间D无差异。HGG组的f值（17.5±6.3%）显著高于LGG组（5.8±3.8%；P <.0001），且与相对脑血容量相关（r = 0.85；P <.0001）。受试者操作特征分析显示，f的曲线下面积为0.95，D为0.78，ADC为0.73，D为0.60。
IVIM成像有助于鉴别HGG与LGG。
