抑郁症中功能失调的奖赏处理
Dysfunctional Reward Processing in Depression.
作者信息
Admon Roee, Pizzagalli Diego A
机构信息
McLean Hospital and Harvard Medical School.
出版信息
Curr Opin Psychol. 2015 Aug 1;4:114-118. doi: 10.1016/j.copsyc.2014.12.011.
Abstract
Anhedonia - diminished pleasure and/or decreased reactivity to pleasurable stimuli - is a core feature of depression that frequently persists after treatment. As a result, extensive effort has been directed towards characterizing the psychological and biological processes that mediate dysfunctional reward processing in depression. Reward processing can be parsed into sub-components that include motivation, reinforcement learning, and hedonic capacity, which, according to preclinical and neuroimaging evidence, involve partially dissociable brain systems. In line with this, recent findings indicate that behavioral impairments and neural abnormalities in depression vary across distinct reward-related constructs. Ultimately, improved understanding of precise reward-related dysfunctions in depression promises to improve diagnostic and therapeutic efforts in depression.
摘要
快感缺失——愉悦感降低和/或对愉悦刺激的反应性降低——是抑郁症的一个核心特征，在治疗后常常持续存在。因此，人们付出了大量努力来刻画介导抑郁症中功能失调的奖赏处理的心理和生物学过程。奖赏处理可细分为包括动机、强化学习和享乐能力在内的子成分，根据临床前和神经影像学证据，这些子成分涉及部分可分离的脑系统。与此一致的是，最近的研究结果表明，抑郁症中的行为障碍和神经异常在不同的奖赏相关结构中有所不同。最终，更好地理解抑郁症中与奖赏相关的确切功能障碍有望改善抑郁症的诊断和治疗工作。
相似文献
1
Dysfunctional Reward Processing in Depression.抑郁症中功能失调的奖赏处理
Curr Opin Psychol. 2015 Aug 1;4:114-118. doi: 10.1016/j.copsyc.2014.12.011.
2
Mechanisms Underlying Motivational Deficits in Psychopathology: Similarities and Differences in Depression and Schizophrenia.精神病理学中动机缺陷的潜在机制：抑郁症和精神分裂症的异同
Curr Top Behav Neurosci. 2016;27:411-49. doi: 10.1007/7854_2015_376.
3
Evolution of anhedonia in adolescent depression: An interpretative phenomenological analysis study.青少年抑郁症快感缺失的演变：一项诠释现象学分析研究。
Clin Child Psychol Psychiatry. 2024 Apr;29(2):564-576. doi: 10.1177/13591045231223862. Epub 2023 Dec 25.
4
Neural mechanisms of reinforcement learning in unmedicated patients with major depressive disorder.未服药的重性抑郁障碍患者强化学习的神经机制。
Brain. 2017 Apr 1;140(4):1147-1157. doi: 10.1093/brain/awx025.
5
[Anhedonia in depression].[抑郁症中的快感缺乏]
Encephale. 2013 Sep;39(4):296-305. doi: 10.1016/j.encep.2013.07.001. Epub 2013 Aug 12.
6
Translational Assessment of Reward and Motivational Deficits in Psychiatric Disorders.精神疾病中奖励与动机缺陷的转化评估
Curr Top Behav Neurosci. 2016;28:231-62. doi: 10.1007/7854_2015_5004.
7
Reward systems and cognitions in Major Depressive Disorder.重性抑郁障碍中的奖励系统和认知。
CNS Spectr. 2019 Feb;24(1):64-77. doi: 10.1017/S1092852918001335. Epub 2018 Nov 26.
8
Pleasure, Reward Value, Prediction Error and Anhedonia.愉悦、奖赏价值、预测误差和快感缺失。
Curr Top Behav Neurosci. 2022;58:281-304. doi: 10.1007/7854_2021_295.
9
The neurobiology of anhedonia and other reward-related deficits.快感缺失和其他与奖励相关的缺陷的神经生物学。
Trends Neurosci. 2012 Jan;35(1):68-77. doi: 10.1016/j.tins.2011.11.005. Epub 2011 Dec 15.
10
Involvement of basal ganglia and orbitofrontal cortex in goal-directed behavior.基底神经节和眶额皮质在目标导向行为中的参与。
Prog Brain Res. 2000;126:193-215. doi: 10.1016/S0079-6123(00)26015-9.
引用本文的文献
1
Neurocognitive Biotypes of Risk and Resilience for Mood Disorders in Adolescents: Insights From Behavioral and Graph-Theoretic Network Markers.青少年情绪障碍风险与恢复力的神经认知生物型：行为和图论网络标记的见解
Biol Psychiatry Glob Open Sci. 2025 Jul 8;5(6):100563. doi: 10.1016/j.bpsgos.2025.100563. eCollection 2025 Nov.
2
Reward Network Activations of Win Versus Loss in a Monetary Gambling Task.金钱赌博任务中赢与输时奖励网络的激活情况。
Behav Sci (Basel). 2025 Jul 22;15(8):994. doi: 10.3390/bs15080994.
3
The role of reward-related brain activity in response to treatment and later depression severity: data from a randomized controlled trial in early adolescents with anxiety disorders.奖赏相关脑活动在应对治疗及后续抑郁严重程度方面的作用：来自一项针对患有焦虑症的青少年早期患者的随机对照试验的数据。
Transl Psychiatry. 2025 Aug 16;15(1):286. doi: 10.1038/s41398-025-03388-2.
4
Individualized functional brain mapping machine learning prediction of symptom-change resulting from selective kappa-opioid antagonism in an anhedonic sample from a Fast-Fail trial.在一项快速失败试验的快感缺失样本中，基于个性化功能脑图谱的机器学习对选择性κ-阿片受体拮抗剂引起的症状变化进行预测。
J Mood Anxiety Disord. 2025 May 9;11:100126. doi: 10.1016/j.xjmad.2025.100126. eCollection 2025 Sep.
5
Male and female mice are similarly susceptible to chronic nondiscriminatory social defeat stress despite differences in attack frequency from aggressor.尽管雄性和雌性小鼠受到攻击者攻击的频率存在差异，但它们对慢性非歧视性社会挫败应激的易感性相似。
Psychopharmacology (Berl). 2025 Jul 12. doi: 10.1007/s00213-025-06858-z.
6
Framework for Brain-Derived Dimensions of Psychopathology.精神病理学脑源性维度框架
JAMA Psychiatry. 2025 Jun 18. doi: 10.1001/jamapsychiatry.2025.1246.
7
Parent-adolescent closeness predicts neurophysiological reward responsiveness in adolescent girls at varying risk for depression.亲子亲密关系可预测不同抑郁风险水平的青春期女孩的神经生理奖励反应性。
Dev Cogn Neurosci. 2025 Jun 3;74:101579. doi: 10.1016/j.dcn.2025.101579.
8
Disgusted, but amused: positive emotion attenuates disgust elicited by film clips.厌恶却又觉得好笑：积极情绪会减弱电影片段引发的厌恶感。
Front Psychol. 2025 May 14;16:1565884. doi: 10.3389/fpsyg.2025.1565884. eCollection 2025.
9
Neural activity to reward and loss predicting treatment outcomes for adults with generalized anxiety disorder: A randomized clinical trial.预测广泛性焦虑症成人治疗结果的奖励与损失相关神经活动：一项随机临床试验。
J Mood Anxiety Disord. 2025 Mar;9. doi: 10.1016/j.xjmad.2025.100107. Epub 2025 Jan 8.
10
Chronic administration of methocinnamox, a mu-opioid receptor antagonist, reduces hedonic response without impacting motivation in mice.长期给予μ-阿片受体拮抗剂甲氧辛胺可降低小鼠的享乐反应，而不影响其动机。
Psychopharmacology (Berl). 2025 May 10. doi: 10.1007/s00213-025-06801-2.
本文引用的文献
1
Single rodent mesohabenular axons release glutamate and GABA.单个啮齿动物中缰核轴突释放谷氨酸和γ-氨基丁酸。
Nat Neurosci. 2014 Nov;17(11):1543-51. doi: 10.1038/nn.3823. Epub 2014 Sep 21.
2
Methodological approaches and magnitude of the clinical unmet need associated with amotivation in mood disorders.与心境障碍中动机缺乏相关的临床未满足需求的方法学途径及程度。
J Affect Disord. 2014 Oct;168:439-51. doi: 10.1016/j.jad.2014.06.056. Epub 2014 Jul 10.
3
Dissociable cortico-striatal connectivity abnormalities in major depression in response to monetary gains and penalties.重度抑郁症患者在面对金钱得失时，皮质-纹状体连接性异常可分离。
Psychol Med. 2015 Jan;45(1):121-31. doi: 10.1017/S0033291714001123. Epub 2014 May 15.
4
Major depression in mothers predicts reduced ventral striatum activation in adolescent female offspring with and without depression.母亲的重度抑郁症可预测患有和不患有抑郁症的青春期女性后代的腹侧纹状体激活减少。
J Abnorm Psychol. 2014 May;123(2):298-309. doi: 10.1037/a0036191.
5
Depression, stress, and anhedonia: toward a synthesis and integrated model.抑郁、压力与快感缺失：迈向一种综合与整合模型
Annu Rev Clin Psychol. 2014;10:393-423. doi: 10.1146/annurev-clinpsy-050212-185606.
6
Learning from negative feedback in patients with major depressive disorder is attenuated by SSRI antidepressants.SSRIs 类抗抑郁药可削弱重度抑郁症患者从负性反馈中学习的能力。
Front Integr Neurosci. 2013 Sep 23;7:67. doi: 10.3389/fnint.2013.00067. eCollection 2013.
7
Blunted reward responsiveness in remitted depression.缓解期抑郁症患者的奖赏反应迟钝。
J Psychiatr Res. 2013 Dec;47(12):1864-9. doi: 10.1016/j.jpsychires.2013.08.011. Epub 2013 Sep 8.
8
Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin.社会奖励需要伏隔核催产素和血清素的协调活动。
Nature. 2013 Sep 12;501(7466):179-84. doi: 10.1038/nature12518.
9
Mapping anhedonia onto reinforcement learning: a behavioural meta-analysis.将快感缺失映射到强化学习：一项行为荟萃分析。
Biol Mood Anxiety Disord. 2013 Jun 19;3(1):12. doi: 10.1186/2045-5380-3-12.
10
Neural correlates of rapid antidepressant response to ketamine in treatment-resistant unipolar depression: a preliminary positron emission tomography study.快速抗抑郁反应的神经相关性 ： 氯胺酮治疗难治性单相抑郁的初步正电子发射断层扫描研究。
Biol Psychiatry. 2013 Jun 15;73(12):1213-21. doi: 10.1016/j.biopsych.2013.02.008. Epub 2013 Mar 27.
Zotero 插件