治疗：T2DM 合并晚期 CKD 患者使用二甲双胍的风险。
Therapy: Risk of metformin use in patients with T2DM and advanced CKD.
机构信息
Rudolfstiftung Hospital, Department of Medicine 1, Juchgasse 25, 1030 Vienna, Austria.
Clinical Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
出版信息
Nat Rev Endocrinol. 2015 Dec;11(12):697-9. doi: 10.1038/nrendo.2015.132. Epub 2015 Aug 18.
In a new study published in The Lancet Diabetes & Endocrinology, metformin use is associated with significantly increased all-cause mortality in patients with type 2 diabetes mellitus and stage 5 chronic kidney disease (CKD). The findings support current recommendations that metformin should not be used in patients with stage 5 CKD.
在《柳叶刀·糖尿病与内分泌学》上发表的一项新研究中，二甲双胍的使用与 2 型糖尿病合并 5 期慢性肾脏病（CKD）患者的全因死亡率显著增加相关。这些发现支持了目前的建议，即不应该在 5 期 CKD 患者中使用二甲双胍。
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