Rudolfstiftung Hospital, Department of Medicine 1, Juchgasse 25, 1030 Vienna, Austria.
Clinical Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
Nat Rev Endocrinol. 2015 Dec;11(12):697-9. doi: 10.1038/nrendo.2015.132. Epub 2015 Aug 18.
In a new study published in The Lancet Diabetes & Endocrinology, metformin use is associated with significantly increased all-cause mortality in patients with type 2 diabetes mellitus and stage 5 chronic kidney disease (CKD). The findings support current recommendations that metformin should not be used in patients with stage 5 CKD.
在《柳叶刀·糖尿病与内分泌学》上发表的一项新研究中，二甲双胍的使用与 2 型糖尿病合并 5 期慢性肾脏病（CKD）患者的全因死亡率显著增加相关。这些发现支持了目前的建议，即不应该在 5 期 CKD 患者中使用二甲双胍。
