Tanner S Bobo, Harwell Susan A
Vanderbilt University Medical Center - Rheumatology and Allergy, 2611 West End Ave, Suite 210, Nashville, Tennessee 37203, USA.
Vanderbilt University Medical Center - Rheumatology, 1161 21st Avenue So., T-3113 MCN, Nashville, Tennessee 37232, USA.
Ther Adv Musculoskelet Dis. 2015 Aug;7(4):152-9. doi: 10.1177/1759720X15588521.
Vitamin D has known importance to bone health including calcium and phosphate homeostasis and appears to have a role in skeletal muscle health as well. Cases of vitamin D deficiency and insufficiency have been associated with poor muscle health. While the exact effects and mechanism of action remains controversial, current data lean towards insufficient vitamin D playing a role in musculoskeletal pain, sarcopenia, myopathy, falls and indirectly via cerebellar and cognitive dysfunction. Sophisticated experimental techniques have allowed detection of the vitamin D receptor (VDR) on skeletal muscle and cerebellar tissue, which if validated in further large studies, could confirm the mechanism of vitamin D in these associations. While further study is required, vitamin D repletion can have a substantial impact on muscle as well as bone health.
维生素D对骨骼健康具有重要意义，包括钙和磷的稳态，并且似乎在骨骼肌健康中也发挥作用。维生素D缺乏和不足的情况与肌肉健康不佳有关。虽然确切的作用和作用机制仍存在争议，但目前的数据倾向于认为维生素D不足在肌肉骨骼疼痛、肌肉减少症、肌病、跌倒以及通过小脑和认知功能障碍间接发挥作用。先进的实验技术已能够检测到骨骼肌和小脑组织上的维生素D受体（VDR），如果在进一步的大型研究中得到验证，可能会证实维生素D在这些关联中的作用机制。虽然还需要进一步研究，但补充维生素D对肌肉和骨骼健康都可能产生重大影响。
