Li Jie, Ding Jie, Zhai Kan
Department of General Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Medical Research Center, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
PLoS One. 2015 Aug 21;10(8):e0136050. doi: 10.1371/journal.pone.0136050. eCollection 2015.
The presence of HPV in breast tissue and the potential causal association between human papillomavirus (HPV) and breast cancer (BC) remains controversial. The aim of the present study was to compare the HPV prevalence in BC tissues, adjacent normal breast tissues and breast benign disease tissues and to investigate the possible association between HPV and breast tumor development in Chinese women. Paraffin-embedded specimens from 187 pairs of BCs including tumor and normal breast tissue adjacent to tumors and 92 breast benign lesions between June 2009 and July 2014 were investigated by nested polymerase chain reaction (PCR) and type-specific PCR, respectively. With strictly quality control, HPV positive infection was detected in three BC tissues. No HPV positive infection was detected in all normal breast tissue adjacent to tumors and benign breast tissues. Through our detailed analysis, rare HPV infection in this study suggests that HPV might not be associated with BC progression.
人乳头瘤病毒（HPV）在乳腺组织中的存在以及HPV与乳腺癌（BC）之间潜在的因果关联仍存在争议。本研究的目的是比较BC组织、相邻正常乳腺组织和乳腺良性疾病组织中HPV的患病率，并调查中国女性中HPV与乳腺肿瘤发生之间的可能关联。分别采用巢式聚合酶链反应（PCR）和型特异性PCR对2009年6月至2014年7月期间187对包含肿瘤及肿瘤相邻正常乳腺组织的BC组织以及92例乳腺良性病变的石蜡包埋标本进行了研究。在严格的质量控制下，在3例BC组织中检测到HPV阳性感染。在所有肿瘤相邻正常乳腺组织和乳腺良性组织中均未检测到HPV阳性感染。通过我们的详细分析，本研究中罕见的HPV感染表明HPV可能与BC进展无关。
