Ahangar-Oskouee Mahin, Shahmahmoodi Shohreh, Jalilvand Somayeh, Mahmoodi Mahmood, Ziaee Abed Ali, Esmaeili Heidar-Ali, Keshtvarz Maryam, Pishraft-Sabet Leila, Yousefi Maryam, Mollaei-Kandelous Yaghoob, Mokhtari-Azad Talat, Nategh Rakhshandeh
Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran E-mail :
Asian Pac J Cancer Prev. 2014;15(9):4061-5. doi: 10.7314/apjcp.2014.15.9.4061.
The presence of viral DNA in breast cancer cells is controversial. However, some studies have revealed a possible role for the human papillomavirus in the pathogenesis of breast cancer. The aim of the present study was to investigate the presence of HPV-DNA in breast tissue in a group of Iranian women with and without breast cancer and identification of the detected HPV types. Paraffin-embedded specimens from 65 malignant breast cancer cases and 65 cases with benign breast lesions were investigated for presence of HPV-DNA by nested polymerase chain reaction. We found HPV-DNA in 22 (33.8%) of the breast cancer specimens. All non-cancerous specimens were negative. Low and high-risk HPV types, including HPV-6 (26.2%), HPV-16 (1.5%), HPV-35 (1.5%), HPV-52 (1.5%), and HPV-11 (1.5%) were detected in our study. HPV-6 was the most prevalent type in the breast cancer specimens. Although high-risk HPV types have been shown to have a major role in cervix cancer, there have been no data that support the same relevance for other types of malignancies. Furthermore, presence of low-risk HPV types in malignancies still is a matter of debate. The data presented in this study indicates a strong need for epidemiological studies correlating different HPV types in human breast cancer.
乳腺癌细胞中病毒DNA的存在存在争议。然而，一些研究揭示了人乳头瘤病毒在乳腺癌发病机制中可能发挥的作用。本研究的目的是调查一组患有和未患乳腺癌的伊朗女性乳腺组织中HPV-DNA的存在情况，并鉴定检测到的HPV类型。通过巢式聚合酶链反应对65例乳腺恶性肿瘤病例和65例乳腺良性病变病例的石蜡包埋标本进行HPV-DNA检测。我们在22例（33.8%）乳腺癌标本中发现了HPV-DNA。所有非癌标本均为阴性。在我们的研究中检测到了低风险和高风险的HPV类型，包括HPV-6（26.2%）、HPV-16（1.5%）、HPV-35（1.5%）、HPV-52（1.5%）和HPV-11（1.5%）。HPV-6是乳腺癌标本中最常见的类型。尽管高风险HPV类型已被证明在宫颈癌中起主要作用，但尚无数据支持其与其他类型恶性肿瘤具有相同的相关性。此外，恶性肿瘤中低风险HPV类型的存在仍然存在争议。本研究提供的数据表明，迫切需要开展流行病学研究，以关联人类乳腺癌中不同的HPV类型。
