用于天然组织微环境中动态基因表达谱分析的单细胞纳米生物传感器。
Single cell nanobiosensors for dynamic gene expression profiling in native tissue microenvironments.
机构信息
Department of Aerospace and Mechanical Engineering, The University of Arizona, Tucson, AZ, 85721, USA.
Harvard-MIT Health Sciences and Technology, Massachusetts Institute of Technology and Harvard Medical School, Cambridge, MA, 02139, USA.
出版信息
Adv Mater. 2015 Oct 21;27(39):6034-8. doi: 10.1002/adma.201502814. Epub 2015 Aug 28.
A gold nanorod-locked nucleic acid nano-biosensor for dynamic single-cell gene expression analysis in living cells and tissues is developed. The nanoparticle facilitates endocytic delivery and dynamic monitoring of the gene expression in human umbilical cord endothelial cells, mouse skin tissues, mouse retina tissues, and mouse cornea tissues at the single-cell level.
一种金纳米棒锁核酸纳米生物传感器，用于活细胞和组织中动态单细胞基因表达分析。该纳米颗粒有助于在单细胞水平上进行人脐静脉内皮细胞、小鼠皮肤组织、小鼠视网膜组织和小鼠角膜组织中的基因表达的内吞递送和动态监测。
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