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血小板在急性呼吸窘迫综合征发病机制中的作用

Platelets in the pathogenesis of acute respiratory distress syndrome.

作者信息

Yadav Hemang, Kor Daryl J

机构信息

Department of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota; and.

Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota

出版信息

Am J Physiol Lung Cell Mol Physiol. 2015 Nov 1;309(9):L915-23. doi: 10.1152/ajplung.00266.2015. Epub 2015 Aug 28.

DOI:10.1152/ajplung.00266.2015
PMID:26320157
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4628982/
Abstract

Platelets have an emerging and incompletely understood role in a myriad of host immune responses, extending their role well beyond regulating thrombosis. Acute respiratory distress syndrome is a complex disease process characterized by a range of pathophysiologic processes including oxidative stress, lung deformation, inflammation, and intravascular coagulation. The objective of this review is to summarize existing knowledge on platelets and their putative role in the development and resolution of lung injury.

摘要

血小板在众多宿主免疫反应中发挥着新的且尚未完全明确的作用，其作用远不止于调节血栓形成。急性呼吸窘迫综合征是一种复杂的疾病过程，其特征在于一系列病理生理过程，包括氧化应激、肺变形、炎症和血管内凝血。本综述的目的是总结关于血小板及其在肺损伤发生和消退中假定作用的现有知识。

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Aspirin therapy in patients with acute respiratory distress syndrome (ARDS) is associated with reduced intensive care unit mortality: a prospective analysis.急性呼吸窘迫综合征（ARDS）患者的阿司匹林治疗与重症监护病房死亡率降低相关：一项前瞻性分析。
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