Centre for DNA Nanotechnology, Interdisciplinary Nanoscience Center, iNANO, Aarhus University, Gustav Wieds Vej 14, 8000 Aarhus C, Denmark.
Department of Chemistry, Aarhus University, Langelandsgade 140, 8000 Aarhus C, Denmark.
Nat Nanotechnol. 2015 Oct;10(10):892-8. doi: 10.1038/nnano.2015.190. Epub 2015 Aug 31.
Synthetic polymers are ubiquitous in the modern world, but our ability to exert control over the molecular conformation of individual polymers is very limited. In particular, although the programmable self-assembly of oligonucleotides and proteins into artificial nanostructures has been demonstrated, we currently lack the tools to handle other types of synthetic polymers individually and thus the ability to utilize and study their single-molecule properties. Here we show that synthetic polymer wires containing short oligonucleotides that extend from each repeat can be made to assemble into arbitrary routings. The wires, which can be more than 200 nm in length, are soft and bendable, and the DNA strands allow individual polymers to self-assemble into predesigned routings on both two- and three-dimensional DNA origami templates. The polymers are conjugated and potentially conducting, and could therefore be used to create molecular-scale electronic or optical wires in arbitrary geometries.
合成聚合物在现代世界中无处不在，但我们对单个聚合物分子构象进行控制的能力非常有限。特别是，尽管已经证明寡核苷酸和蛋白质可以可编程地自组装成人工纳米结构，但我们目前缺乏单独处理其他类型合成聚合物的工具，因此也缺乏利用和研究它们单分子性质的能力。在这里，我们展示了含有从每个重复单元延伸出的短寡核苷酸的合成聚合物线可以被组装成任意布线。这些线的长度可以超过 200nm，它们柔软且可弯曲，并且 DNA 链允许单个聚合物在二维和三维 DNA 折纸模板上自组装成预定的布线。聚合物被共轭并具有潜在的导电性，因此可以用于以任意几何形状创建分子尺度的电子或光学线。
