Zhao Jun, Lee Patrick, Wallace Michael J, Melancon Marites P
Department of Interventional Radiology, Unit 1471, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030.
Curr Pharm Des. 2015;21(29):4240-51. doi: 10.2174/1381612821666150901103032.
Gold-based nanoparticles are utilized for cancer therapeutics as a system for drug delivery, or as a mediator for thermal therapy, whether ablation or hyperthermia. This review discusses how the design of the physicochemical properties of the different types of gold-based nanoparticles affects their treatment efficacy. The basic principles and mechanism at which it mediates heating and delivers drugs efficiently in vivo is also summarized. We will also review the in vivo preclinical data on the biodistribution, intratumoral distribution, cell internalization, and its associated toxicity. Lastly, an updated list of the clinical trials based on nanoparticles and future perspectives are provided.
基于金的纳米颗粒被用作癌症治疗的药物递送系统，或用作热疗的介质，无论是消融还是热疗。本综述讨论了不同类型的基于金的纳米颗粒的物理化学性质设计如何影响其治疗效果。还总结了其在体内有效介导加热和递送药物的基本原理和机制。我们还将综述关于生物分布、肿瘤内分布、细胞内化及其相关毒性的体内临床前数据。最后，提供了基于纳米颗粒的临床试验的最新列表和未来展望。
