来自猪源耐利奈唑胺屎肠球菌分离株的新型质粒介导多药耐药基因簇，包括lsa(E) 。
Novel plasmid-borne multidrug resistance gene cluster including lsa(E) from a linezolid-resistant Enterococcus faecium isolate of swine origin.
作者信息
Si Hongbin, Zhang Wan-Jiang, Chu Shengbo, Wang Xiu-Mei, Dai Lei, Hua Xin, Dong Zhimin, Schwarz Stefan, Liu Siguo
机构信息
College of Animal Sciences and Technology, Guangxi University, Nanning, China.
State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.
出版信息
Antimicrob Agents Chemother. 2015 Nov;59(11):7113-6. doi: 10.1128/AAC.01394-15. Epub 2015 Aug 31.
Abstract
A novel nonconjugative plasmid of 28,489 bp from a porcine linezolid-resistant Enterococcus faecium isolate was completely sequenced. This plasmid harbored a novel type of multiresistance gene cluster that comprised the resistance genes lnu(B), lsa(E), spw, aadE, aphA3, and two copies of erm(B), which account for resistance to macrolides, lincosamides, streptogramins, pleuromutilins, streptomycin, spectinomycin, and kanamycin/neomycin. Structural comparisons suggested that this plasmid might have developed from other enterococcal plasmids by insertion element (IS)-mediated interplasmid recombination processes.
摘要
对一株来自猪的耐利奈唑胺屎肠球菌分离株中一个28489 bp的新型非接合质粒进行了全序列测定。该质粒含有一种新型多耐药基因簇，其中包括耐药基因lnu(B)、lsa(E)、spw、aadE、aphA3以及两个erm(B)拷贝，这些基因赋予对大环内酯类、林可酰胺类、链阳菌素类、截短侧耳素类、链霉素、壮观霉素以及卡那霉素/新霉素的耐药性。结构比较表明，该质粒可能是通过插入元件（IS）介导的质粒间重组过程从其他肠球菌质粒进化而来。
相似文献
1
Novel plasmid-borne multidrug resistance gene cluster including lsa(E) from a linezolid-resistant Enterococcus faecium isolate of swine origin.来自猪源耐利奈唑胺屎肠球菌分离株的新型质粒介导多药耐药基因簇，包括lsa(E) 。
Antimicrob Agents Chemother. 2015 Nov;59(11):7113-6. doi: 10.1128/AAC.01394-15. Epub 2015 Aug 31.
2
Prevalence and mechanism of resistance against macrolides, lincosamides, and streptogramins among Enterococcus faecium isolates from food-producing animals and hospital patients in Belgium.比利时食品生产动物和医院患者分离出的屎肠球菌中对大环内酯类、林可酰胺类和链阳菌素类抗生素的耐药率及耐药机制
Microb Drug Resist. 2007 Summer;13(2):135-41. doi: 10.1089/mdr.2007.718.
3
Presence and new genetic environment of pleuromutilin-lincosamide-streptogramin A resistance gene lsa(E) in Erysipelothrix rhusiopathiae of swine origin.猪源猪丹毒丝菌中截短侧耳素-林可酰胺-链阳菌素A耐药基因lsa(E)的存在及其新的遗传环境
Vet Microbiol. 2015 May 15;177(1-2):162-7. doi: 10.1016/j.vetmic.2015.02.014. Epub 2015 Feb 25.
4
Detection and new genetic environment of the pleuromutilin-lincosamide-streptogramin A resistance gene lsa(E) in methicillin-resistant Staphylococcus aureus of swine origin.猪源耐甲氧西林金黄色葡萄球菌中培南类-林可酰胺-链阳菌素 A 类耐药基因 lsa(E)的检测及新的遗传环境
J Antimicrob Chemother. 2013 Jun;68(6):1251-5. doi: 10.1093/jac/dkt015. Epub 2013 Feb 5.
5
Novel multiresistance cfr plasmids in linezolid-resistant methicillin-resistant Staphylococcus epidermidis and vancomycin-resistant Enterococcus faecium (VRE) from a hospital outbreak: co-location of cfr and optrA in VRE.耐万古霉素肠球菌（VRE）和耐甲氧西林表皮葡萄球菌（MRSE）中与利奈唑胺耐药相关的新型多重耐药 cfr 质粒：VRE 中 cfr 和 optrA 的共存。
J Antimicrob Chemother. 2017 Dec 1;72(12):3252-3257. doi: 10.1093/jac/dkx292.
6
Resistance to macrolides, lincosamides, streptogramins, and linezolid among members of the Staphylococcus sciuri group.松鼠葡萄球菌属成员对大环内酯类、林可酰胺类、链阳菌素类和利奈唑胺的耐药性
Microb Drug Resist. 2006 Summer;12(2):115-20. doi: 10.1089/mdr.2006.12.115.
7
Novel Structure of Enterococcus faecium-Originated ermB-Positive Tn1546-Like Element in Staphylococcus aureus.金黄色葡萄球菌中源自粪肠球菌的ermB阳性Tn1546样元件的新结构
Antimicrob Agents Chemother. 2016 Sep 23;60(10):6108-14. doi: 10.1128/AAC.01096-16. Print 2016 Oct.
8
Identification of a novel vga(E) gene variant that confers resistance to pleuromutilins, lincosamides and streptogramin A antibiotics in staphylococci of porcine origin.鉴定一种新型 vga(E) 基因变异体，该变异体赋予猪源葡萄球菌对截短侧耳素类、林可酰胺类和链阳性菌素 A 类抗生素的耐药性。
J Antimicrob Chemother. 2014 Apr;69(4):919-23. doi: 10.1093/jac/dkt482. Epub 2013 Dec 8.
9
Genetic basis for in vitro and in vivo resistance to lincosamides, streptogramins A, and pleuromutilins (LSAP phenotype) in Enterococcus faecium.肠球菌对林可酰胺类、链阳性菌素 A 和截短侧耳素（LSAP 表型）的体外和体内耐药的遗传基础。
Antimicrob Agents Chemother. 2013 Sep;57(9):4463-9. doi: 10.1128/AAC.01030-13. Epub 2013 Jul 8.
10
Conjugal transfer of aminoglycoside and macrolide resistance between Enterococcus faecium isolates in the intestine of streptomycin-treated mice.链霉素处理小鼠肠道内屎肠球菌分离株间氨基糖苷类和大环内酯类耐药性的接合转移
FEMS Microbiol Lett. 2004 Jun 15;235(2):385-91. doi: 10.1016/j.femsle.2004.04.050.
引用本文的文献
1
Recent development and fighting strategies for lincosamide antibiotic resistance.林可酰胺类抗生素耐药性的最新研究进展与应对策略。
Clin Microbiol Rev. 2024 Jun 13;37(2):e0016123. doi: 10.1128/cmr.00161-23. Epub 2024 Apr 18.
2
Optimization of loop-mediated isothermal amplification-based method for detection of macrolide-lincosamide-streptogramin B resistance in .基于环介导等温扩增法检测大环内酯-林可酰胺-链阳菌素B耐药性的方法优化
Indian J Med Res. 2023 May;157(5):477-481. doi: 10.4103/ijmr.ijmr_3304_21.
3
Characterization of Streptococcus equi subsp. zooepidemicus isolates containing lnuB gene responsible for the L phenotype.鉴定含有 lnuB 基因的马链球菌兽疫亚种分离株，lnuB 基因负责 L 表型。
PLoS One. 2023 Apr 28;18(4):e0284869. doi: 10.1371/journal.pone.0284869. eCollection 2023.
4
Serotypes, Antibiotic Susceptibility, Genotypic Virulence Profiles and SpaA Variants of Strains Isolated from Pigs in Poland.从波兰猪中分离出的菌株的血清型、抗生素敏感性、基因型毒力谱和 SpaA 变体
Pathogens. 2023 Mar 3;12(3):409. doi: 10.3390/pathogens12030409.
5
Tn, a Novel Tn Family Transposon from Porcine Methicillin-Resistant Staphylococcus aureus ST398, Carries a Multiresistance Gene Cluster Comprising a Novel Gene Variant and the Genes (E) and (B).Tn，一种来自猪源耐甲氧西林金黄色葡萄球菌ST398的新型Tn家族转座子，携带一个多抗性基因簇，该基因簇包含一个新型基因变体以及（E）和（B）基因。
Antimicrob Agents Chemother. 2022 Apr 19;66(4):e0194721. doi: 10.1128/aac.01947-21. Epub 2022 Mar 22.
6
Characterization and Comparison of spp. Isolates from Feces of Healthy Dogs and Urine of Dogs with UTIs.来自健康犬粪便和患有泌尿道感染犬尿液的 spp. 分离株的特征分析与比较。
Animals (Basel). 2021 Sep 29;11(10):2845. doi: 10.3390/ani11102845.
7
A Conjugative MDR pMG1-Like Plasmid Carrying the (E) Gene of With Potential Transmission to .一种携带（E）基因的接合型多药耐药pMG1样质粒，具有向……潜在传播的可能性。
Front Microbiol. 2021 Jun 4;12:667415. doi: 10.3389/fmicb.2021.667415. eCollection 2021.
8
Molecular Characterization of Isolates From Different Sources in Estonia Reveals Potential Transmission of Resistance Genes Among Different Reservoirs.爱沙尼亚不同来源分离株的分子特征揭示了耐药基因在不同宿主间的潜在传播。
Front Microbiol. 2021 Mar 26;12:601490. doi: 10.3389/fmicb.2021.601490. eCollection 2021.
9
Multidrug Resistance (MDR) and Collateral Sensitivity in Bacteria, with Special Attention to Genetic and Evolutionary Aspects and to the Perspectives of Antimicrobial Peptides-A Review.细菌中的多药耐药性（MDR）与协同敏感性，特别关注遗传和进化方面以及抗菌肽的前景——综述
Pathogens. 2020 Jun 29;9(7):522. doi: 10.3390/pathogens9070522.
10
Identification and antibiotic susceptibility of lactobacilli isolated from turkeys.从火鸡中分离的乳酸菌的鉴定和药敏试验。
BMC Microbiol. 2018 Oct 29;18(1):168. doi: 10.1186/s12866-018-1269-6.
本文引用的文献
1
Identification of ABC transporter genes conferring combined pleuromutilin-lincosamide-streptogramin A resistance in bovine methicillin-resistant Staphylococcus aureus and coagulase-negative staphylococci.在牛耐甲氧西林金黄色葡萄球菌和凝固酶阴性葡萄球菌中鉴定赋予截短侧耳素-林可酰胺-链阳菌素A联合耐药性的ABC转运蛋白基因
Vet Microbiol. 2015 Jun 12;177(3-4):353-8. doi: 10.1016/j.vetmic.2015.03.027. Epub 2015 Apr 8.
2
Presence and new genetic environment of pleuromutilin-lincosamide-streptogramin A resistance gene lsa(E) in Erysipelothrix rhusiopathiae of swine origin.猪源猪丹毒丝菌中截短侧耳素-林可酰胺-链阳菌素A耐药基因lsa(E)的存在及其新的遗传环境
Vet Microbiol. 2015 May 15;177(1-2):162-7. doi: 10.1016/j.vetmic.2015.02.014. Epub 2015 Feb 25.
3
Novel conjugative plasmid from Escherichia coli of swine origin that coharbors the multiresistance gene cfr and the extended-spectrum-β-lactamase gene blaCTX-M-14b.来自猪源大肠杆菌的新型接合质粒，其共携带多抗性基因cfr和超广谱β-内酰胺酶基因blaCTX-M-14b。
Antimicrob Agents Chemother. 2015 Feb;59(2):1337-40. doi: 10.1128/AAC.04631-14. Epub 2014 Nov 24.
4
Characterization of a multidrug resistance plasmid from Enterococcus faecium that harbours a mobilized bcrABDR locus.对一株携带可移动bcrABDR基因座的粪肠球菌多药耐药质粒的特征分析
J Antimicrob Chemother. 2015 Feb;70(2):609-11. doi: 10.1093/jac/dku416. Epub 2014 Oct 16.
5
Genetic environment of the lnu(B) gene in a Streptococcus agalactiae clinical isolate.无乳链球菌临床分离株中lnu(B)基因的遗传环境。
Antimicrob Agents Chemother. 2014 Sep;58(9):5636-7. doi: 10.1128/AAC.02630-14. Epub 2014 Jun 23.
6
Mechanisms of linezolid resistance among coagulase-negative staphylococci determined by whole-genome sequencing.通过全基因组测序确定凝固酶阴性葡萄球菌对利奈唑胺耐药的机制。
mBio. 2014 May 13;5(3):e00894-14. doi: 10.1128/mBio.00894-14.
7
Characterization of methicillin-resistant coagulase-negative staphylococci in milk from cows with mastitis in Brazil.巴西患乳腺炎奶牛所产牛奶中耐甲氧西林凝固酶阴性葡萄球菌的特性分析。
Antonie Van Leeuwenhoek. 2014 Aug;106(2):227-33. doi: 10.1007/s10482-014-0185-5. Epub 2014 May 10.
8
Enterococcal multiresistance gene cluster in methicillin-resistant Staphylococcus aureus from various origins and geographical locations.来自不同来源和地理位置的耐甲氧西林金黄色葡萄球菌中的肠球菌多抗性基因簇。
J Antimicrob Chemother. 2014 Sep;69(9):2573-5. doi: 10.1093/jac/dku137. Epub 2014 May 3.
9
Characterization of sal(A), a novel gene responsible for lincosamide and streptogramin A resistance in Staphylococcus sciuri.松鼠葡萄球菌中负责林可酰胺和链阳菌素A抗性的新基因sal(A)的特性分析
Antimicrob Agents Chemother. 2014 Jun;58(6):3335-41. doi: 10.1128/AAC.02797-13. Epub 2014 Mar 31.
10
Presence and genetic environment of pleuromutilin-lincosamide-streptogramin A resistance gene lsa(E) in enterococci of human and swine origin.人源和猪源肠球菌中截短侧耳素-林可酰胺-链阳菌素A耐药基因lsa(E)的存在情况及遗传环境
J Antimicrob Chemother. 2014 May;69(5):1424-6. doi: 10.1093/jac/dkt502. Epub 2013 Dec 29.
Zotero 插件