Department of Psychiatry, Walter Reed National Military Medical Center, 8901 Wisconsin Ave, Bethesda, MD, 20889, USA.
Curr Psychiatry Rep. 2015 Oct;17(10):83. doi: 10.1007/s11920-015-0621-x.
Patients with post-traumatic stress disorder (PTSD) may fail to achieve adequate relief despite treatment with psychotherapy, pharmacotherapy, or complementary medicine treatments. Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation procedure that can alter neuronal activity through administration of various pulse sequences and frequencies. TMS may theoretically have promise in correcting alterations observed in patients with PTSD. While the precise treatment location and pulse sequences remain undefined, current evidence suggests two promising targets, the right dorsolateral prefrontal cortex and the medial prefrontal cortex. The beneficial effects may be due to the secondary or indirect regulation of other brain structures that may be involved in the mood regulatory network. TMS may be an effective part of a comprehensive treatment program for PTSD, although significant work remains to define optimal treatment parameters and clarify how it fits within a broader traditional treatment program.
创伤后应激障碍（PTSD）患者在接受心理治疗、药物治疗或补充医学治疗后，可能无法获得充分缓解。经颅磁刺激（TMS）是一种非侵入性的大脑刺激程序，通过给予不同的脉冲序列和频率，可以改变神经元的活动。TMS 可能在纠正 PTSD 患者观察到的改变方面具有理论上的潜力。虽然确切的治疗部位和脉冲序列尚不清楚，但目前的证据表明有两个有前途的靶点，即右侧背外侧前额叶皮层和内侧前额叶皮层。其有益效果可能是由于对其他可能参与情绪调节网络的脑结构的二次或间接调节。TMS 可能是 PTSD 综合治疗计划的有效组成部分，尽管仍需要大量工作来确定最佳治疗参数，并阐明它如何适应更广泛的传统治疗计划。
