Claborn Kasey R, Fernandez Anne, Wray Tyler, Ramsey Susan
Center for Alcohol and Addiction Studies and the Alcohol Research Center on HIV, Brown University, Providence, RI 02912 USA ; 121 South Main Street, Providence, RI 02903 USA.
Center for Alcohol and Addiction Studies and the Alcohol Research Center on HIV, Brown University, Providence, RI 02912 USA.
Transl Behav Med. 2015 Sep;5(3):294-306. doi: 10.1007/s13142-015-0317-0.
Researchers have instituted a range of methodologies to increase access to HIV adherence interventions. This article reviews studies published through January 2014 utilizing computer-based delivery of such interventions to persons living with HIV. A systematic review of five databases identified ten studies (three RCTs, three pilot studies, three feasibility studies, and one single-group trial) that met the inclusion criteria. Descriptions of the interventions' content and characteristics are included. Interventions varied widely in terms of program structure, theoretical framework, and content. Only six studies reported medication adherence outcomes. Of these, four (five RCTS and one single group pre-post test) reported significant improvement in adherence using various measures, and two approached significance. Results suggest that computer-delivered adherence interventions are feasible and acceptable among both HIV-positive adolescents and adults. Definitive conclusions regarding clinical impact cannot be drawn due to the small number of adequately powered randomized trials in this review. Additional randomized controlled research is needed to draw inferences regarding intervention efficacy.
研究人员已经制定了一系列方法，以增加获得艾滋病毒依从性干预措施的机会。本文回顾了截至2014年1月发表的利用基于计算机的方式向艾滋病毒感染者提供此类干预措施的研究。对五个数据库进行的系统综述确定了十项符合纳入标准的研究（三项随机对照试验、三项试点研究、三项可行性研究和一项单组试验）。文中包含了对干预措施内容和特点的描述。干预措施在项目结构、理论框架和内容方面差异很大。只有六项研究报告了药物依从性结果。其中，四项（五项随机对照试验和一项单组前后测试）报告了使用各种测量方法后依从性有显著改善，两项接近显著水平。结果表明，基于计算机的依从性干预措施在艾滋病毒阳性青少年和成年人中是可行且可接受的。由于本综述中充分有力的随机试验数量较少，无法得出关于临床影响的确切结论。需要更多的随机对照研究来推断干预效果。
