Department of Burn Surgery, The First People's Hospital of Foshan, Foshan, 528000, China.
Department of Human Anatomy, School of Basic Medical Science, Xinjiang Medical University, Urumqi, 830001, China.
Stem Cell Res Ther. 2019 Jul 29;10(1):229. doi: 10.1186/s13287-019-1312-z.
The skin has important barrier, sensory, and immune functions, contributing to the health and integrity of the organism. Extensive skin injuries that threaten the entire organism require immediate and effective treatment. Wound healing is a natural response, but in severe conditions, such as burns and diabetes, this process is insufficient to achieve effective treatment. Epidermal stem cells (EPSCs) are a multipotent cell type and are committed to the formation and differentiation of the functional epidermis. As the contributions of EPSCs in wound healing and tissue regeneration have been increasingly attracting the attention of researchers, a rising number of therapies based on EPSCs are currently under development. In this paper, we review the characteristics of EPSCs and the mechanisms underlying their functions during wound healing. Applications of EPSCs are also discussed to determine the potential and feasibility of using EPSCs clinically in wound healing.
皮肤具有重要的屏障、感觉和免疫功能，有助于机体的健康和完整。广泛威胁整个机体的皮肤损伤需要立即和有效的治疗。伤口愈合是一种自然反应，但在严重情况下，如烧伤和糖尿病，这一过程不足以实现有效治疗。表皮干细胞（EPSCs）是一种多能细胞类型，致力于形成和分化功能性表皮。由于 EPSCs 在伤口愈合和组织再生中的作用越来越受到研究人员的关注，目前正在开发越来越多基于 EPSCs 的疗法。本文综述了 EPSCs 的特征及其在伤口愈合过程中发挥功能的机制。还讨论了 EPSCs 的应用，以确定其在伤口愈合中临床应用的潜力和可行性。
