Li Xiao-Feng, Liu Xian-Feng, Yang Yong-Yan, Liu Ai-Yong, Zhang Mei-Yun, Bai Xue-Feng, Gao Hui, Guo Xiao-Guang
Department of Internal Medicine, Baotou Tumor Hospital No. 18 Tuanjie Street, Qingshan District, Baotou 014030, Neimeng Province, People's Republic of China.
Am J Cancer Res. 2015 Jun 15;5(7):2277-84. eCollection 2015.
To analyze the expressions of Bcl-2, B7-H1, EGFR and VEGF in colorectal cancer for the further investigation of their correlations with the clinical pathological features of colorectal cancer.
Fresh colorectal cancer tissues and the expressions of Bcl-2, B7-H1, VEGF and EGFR in paraneoplastic normal mucosal tissues of 57 cases were tested by immunohistochemisty method, and the results were analyzed by SPSS10.0.
In colorectal carcinoma, Bcl-2, B7-H1, EGFR and VEGF were all expressed, independent from age and depth of invasion. However, the expression level of Bcl-2 and B7-H1 correlated with tissue differentiation, and the latter also had correlation with tumor staging. Meanwhile, the short-term follow-up showed that high expression of Bcl-2/B7-H1 existed in death cases. Therefore, the expression detection of Bcl-2, B7-H1 might provide a clear understanding of the biological behavior of colorectal cancer, and was important for the diagnosis, treatment and prognosis judgment of colorectal cancer.
分析结直肠癌中Bcl-2、B7-H1、表皮生长因子受体（EGFR）和血管内皮生长因子（VEGF）的表达情况，进一步探讨其与结直肠癌临床病理特征的相关性。
采用免疫组织化学方法检测57例结直肠癌患者新鲜癌组织及癌旁正常黏膜组织中Bcl-2、B7-H1、VEGF和EGFR的表达情况，并用SPSS10.0软件进行结果分析。
在结直肠癌中，Bcl-2、B7-H1、EGFR和VEGF均有表达，且与年龄和浸润深度无关。然而，Bcl-2和B7-H1的表达水平与组织分化相关，后者也与肿瘤分期相关。同时，短期随访显示死亡病例中存在Bcl-2/B7-H1高表达。因此，检测Bcl-2、B7-H1的表达可能有助于了解结直肠癌的生物学行为，对结直肠癌的诊断、治疗及预后判断具有重要意义。
