一种用于活细胞中RNA特异性染色和成像的分子荧光染料：一种源自经典噻唑橙和苯乙烯基化合物的新型配体整合体。
A molecular fluorescent dye for specific staining and imaging of RNA in live cells: a novel ligand integration from classical thiazole orange and styryl compounds.
作者信息
Lu Yu-Jing, Deng Qiang, Hu Dong-Ping, Wang Zheng-Ya, Huang Bao-Hua, Du Zhi-Yun, Fang Yan-Xiong, Wong Wing-Leung, Zhang Kun, Chow Cheuk-Fai
机构信息
Institute of Natural Medicine and Green Chemistry, School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, P. R. China.
出版信息
Chem Commun (Camb). 2015 Oct 25;51(83):15241-4. doi: 10.1039/c5cc05551b. Epub 2015 Sep 2.
A new RNA-selective fluorescent dye integrated with a thiazole orange and a p-(methylthio)styryl moiety shows better nucleolus RNA staining and imaging performance in live cells than the commercial stains. It also exhibits excellent photostability, cell tolerance, and counterstain compatibility with 4',6-diamidino-2-phenylindole for specific RNA-DNA colocalization in bioassays.
一种新的整合了噻唑橙和对（甲硫基）苯乙烯基部分的RNA选择性荧光染料，在活细胞中显示出比商业染料更好的核仁RNA染色和成像性能。它还具有出色的光稳定性、细胞耐受性，并且在生物测定中与4',6-二脒基-2-苯基吲哚用于特定RNA-DNA共定位时具有复染兼容性。
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