Park Joo-Man, Jo Seong-Ho, Kim Mi-Young, Kim Tae-Hyun, Ahn Yong-Ho
Department of Biochemistry and Molecular Biology, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, Republic of Korea.
Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, Republic of Korea.
Protein Cell. 2015 Nov;6(11):804-13. doi: 10.1007/s13238-015-0204-y. Epub 2015 Sep 3.
Post-translational modifications (PTMs) of transcription factors play a crucial role in regulating metabolic homeostasis. These modifications include phosphorylation, methylation, acetylation, ubiquitination, SUMOylation, and O-GlcNAcylation. Recent studies have shed light on the importance of lysine acetylation at nonhistone proteins including transcription factors. Acetylation of transcription factors affects subcellular distribution, DNA affinity, stability, transcriptional activity, and current investigations are aiming to further expand our understanding of the role of lysine acetylation of transcription factors. In this review, we summarize recent studies that provide new insights into the role of protein lysine-acetylation in the transcriptional regulation of metabolic homeostasis.
转录因子的翻译后修饰（PTMs）在调节代谢稳态中起着关键作用。这些修饰包括磷酸化、甲基化、乙酰化、泛素化、SUMO化和O-连接的N-乙酰葡糖胺化。最近的研究揭示了包括转录因子在内的非组蛋白蛋白质赖氨酸乙酰化的重要性。转录因子的乙酰化会影响亚细胞分布、DNA亲和力、稳定性、转录活性，目前的研究旨在进一步拓展我们对转录因子赖氨酸乙酰化作用的理解。在本综述中，我们总结了最近的研究，这些研究为蛋白质赖氨酸乙酰化在代谢稳态转录调控中的作用提供了新的见解。
