Guo Liyuan, Zhu Hong, Lin Chengjun, Che Jianhua, Tian Xiujuan, Han Shiyu, Zhao Honghui, Zhu Yumei, Mao Dongwei
Department of Gynecological Oncology, Tumor Hospital of Harbin Medical University, Harbin, China.
Department of Obstetrics and Gynecology, The Fourth Hospital of Harbin Medical University, Harbin, China.
Sci Rep. 2015 Sep 4;5:13607. doi: 10.1038/srep13607.
Previous studies on the associations between dietary antioxidant vitamins and the risk of cervical cancer remain inconsistent, and little evidence is available for serum antioxidant vitamins, which provide more accurate measurements of these nutrients. We conducted a case-control study of 458 incident cases with invasive cervical cancer and 742 controls to assess the effects of diet or serum antioxidant vitamins. Higher serum antioxidant vitamins were associated with a lower risk of cervical cancer after adjusting for potential confounders. The odds ratios (ORs) for the highest (vs. lowest) quartile were 0.66 (95% confidence interval [CI] = 0.46-0.93; P = 0.024) for α-carotene, 0.63 (95% CI = 0.45-0.90; P = 0.006) for β-carotene, 0.53 (95% CI = 0.37-0.74; P < 0.001) for vitamin E, and 0.48 (95% CI = 0.33-0.69; P < 0.001) for vitamin C. Dietary intakes of vitamins E and C were inversely associated with the risk of cervical cancer. Risk of cervical cancer from serum antioxidant vitamins was more evident in passive smokers than non-passive smokers. These findings indicated that antioxidant vitamins (mainly α-carotene, β-carotene, and vitamins E and C) might be beneficial in reducing the risk of invasive cervical cancer in Chinese women, especially in passive smokers.
以往关于膳食抗氧化维生素与宫颈癌风险之间关联的研究结果仍不一致，而关于血清抗氧化维生素的证据较少，血清抗氧化维生素能更准确地衡量这些营养素。我们开展了一项病例对照研究，纳入458例浸润性宫颈癌新发病例和742例对照，以评估饮食或血清抗氧化维生素的作用。在对潜在混杂因素进行调整后，血清抗氧化维生素水平较高与宫颈癌风险较低相关。α-胡萝卜素最高（与最低）四分位数的比值比（OR）为0.66（95%置信区间[CI]=0.46 - 0.93；P=0.024），β-胡萝卜素为0.63（95%CI=0.45 - 0.90；P=0.006），维生素E为0.53（95%CI=0.37 - 0.74；P<0.001），维生素C为0.48（95%CI=0.33 - 0.69；P<0.001）。维生素E和C的膳食摄入量与宫颈癌风险呈负相关。血清抗氧化维生素导致的宫颈癌风险在被动吸烟者中比非被动吸烟者更明显。这些发现表明，抗氧化维生素（主要是α-胡萝卜素、β-胡萝卜素以及维生素E和C）可能有助于降低中国女性浸润性宫颈癌的风险，尤其是在被动吸烟者中。
