库欣综合征患者的亚临床动脉粥样硬化：颈动脉内膜中层厚度和踝臂指数评估。
Subclinical Atherosclerosis in Patients with Cushing Syndrome: Evaluation with Carotid Intima-Media Thickness and Ankle-Brachial Index.
机构信息
Department of Internal Medicine and Medical Specialties, University of Rome "Sapienza", Rome, Italy.
Section Nuclear Medicine, Department of Radiology, University of Rome "Sapienza", Rome, Italy.
出版信息
Endocrinol Metab (Seoul). 2015 Dec;30(4):488-93. doi: 10.3803/EnM.2015.30.4.488. Epub 2015 Sep 10.
BACKGROUND
Cushing syndrome (CS) has been described as a killing disease due its cardiovascular complications. In fact, chronic cortisol excess leads to a constellation of complications, including hypertension, hyperglycemia, adiposity, and thromboembolism. The main vascular alteration associated with CS is atherosclerosis.
METHODS
Aim of this study was to analyze carotid intima-media thickness (cIMT) and ankle-brachial index (ABI), two surrogate markers of subclinical atherosclerosis in a consecutive series of CS patients, compared to patients with essential hypertension (EH) and health subjects (HS).
RESULTS
Patients with CS showed a significant increase (P<0.05) of cIMT (0.89±0.17 mm) compared to EH (0.81±0.16 mm) and HS (0.75±0.4 mm), with a high prevalence of plaque (23%; P<0.03). Moreover, CS patients showed a mean ABI values (1.07±0.02) significantly lower respect to HS (1.12±0.11; P<0.05), and a higher percentage (20%) of pathological values of ABI (≤0.9; P<0.03).
CONCLUSION
In conclusion, we confirmed and extended the data of cIMT in CS, and showed that the ABI represent another surrogate marker of subclinical atherosclerosis in this disease.
背景
库欣综合征（CS）因其心血管并发症而被描述为一种致命疾病。事实上，慢性皮质醇过多会导致一系列并发症，包括高血压、高血糖、肥胖和血栓栓塞。与 CS 相关的主要血管改变是动脉粥样硬化。
方法
本研究旨在分析连续系列 CS 患者的颈动脉内膜中层厚度（cIMT）和踝臂指数（ABI），这两个亚临床动脉粥样硬化的替代标志物，并与原发性高血压（EH）患者和健康受试者（HS）进行比较。
结果
CS 患者的 cIMT（0.89±0.17mm）明显高于 EH（0.81±0.16mm）和 HS（0.75±0.4mm）（P<0.05），斑块的发生率较高（23%；P<0.03）。此外，CS 患者的平均 ABI 值（1.07±0.02）明显低于 HS（1.12±0.11；P<0.05），且 ABI 值异常（≤0.9）的百分比较高（20%；P<0.03）。
结论
总之，我们证实并扩展了 CS 中 cIMT 的数据，并表明 ABI 是该疾病亚临床动脉粥样硬化的另一个替代标志物。
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