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反向性痤疮:诊断与治疗中的难点

Acne inversa: difficulties in diagnostics and therapy.

作者信息

Bergler-Czop Beata, Hadasik Karolina, Brzezińska-Wcisło Ligia

机构信息

Department of Dermatology, Silesian Medical University, Katowice, Poland. Head of the Department: Prof. Ligia Brzezińska-Wcisło MD, PhD.

出版信息

Postepy Dermatol Alergol. 2015 Aug;32(4):296-301. doi: 10.5114/pdia.2014.44012. Epub 2015 Aug 12.

DOI:10.5114/pdia.2014.44012
PMID:26366155
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4565831/
Abstract

Acne inversa (hidradenitis suppurativa) is a potentially severe and chronic inflammatory disease with a significant negative influence on the quality of life. Usually, lesions are located in the areas of skin folds and it is characterized by the presence of painful nodules and fistulas with a tendency to tissue fibrosis. Currently, it is suggested that follicular occlusion by infundibular hyperkeratosis plays a crucial role in pathogenesis and an occupation of apocrine sweat glands is a secondary phenomenon. Most often, it refers to men after puberty. This article tries to present the latest theory concerning the etiology of inverted acne and methods of its treatment. It also describes the most common errors in diagnostic and therapeutic procedures, which are mainly connected with repeated and long antibiotic therapy and not radical surgical treatment.

摘要

化脓性汗腺炎是一种潜在的严重慢性炎症性疾病,对生活质量有重大负面影响。通常,病变位于皮肤褶皱部位,其特征是存在疼痛性结节和瘘管,并伴有组织纤维化倾向。目前认为,漏斗部角化过度导致的毛囊阻塞在发病机制中起关键作用,顶泌汗腺受累是继发现象。此病最常发生于青春期后的男性。本文旨在介绍有关化脓性汗腺炎病因的最新理论及其治疗方法。文中还描述了诊断和治疗过程中最常见的错误,这些错误主要与反复长期使用抗生素治疗以及手术治疗不彻底有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a93f/4565831/ce2a771d0b54/PDIA-32-23146-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a93f/4565831/f9a531dd4622/PDIA-32-23146-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a93f/4565831/ce2a771d0b54/PDIA-32-23146-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a93f/4565831/f9a531dd4622/PDIA-32-23146-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a93f/4565831/ce2a771d0b54/PDIA-32-23146-g002.jpg

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本文引用的文献

1
Acne inversa goes an extra mile than hidradenitis suppurativa.化脓性汗腺炎相比,反向性痤疮的情况更为严重。
Postepy Dermatol Alergol. 2013 Aug;30(4):255-60. doi: 10.5114/pdia.2013.37037. Epub 2013 Aug 27.
2
Hidradenitis suppurativa: A practical review of possible medical treatments based on over 350 hidradenitis patients.化脓性汗腺炎:基于350多名化脓性汗腺炎患者对可能的药物治疗的实用综述
Dermatol Online J. 2013 Apr 15;19(4):1.
3
Failure of anti-interleukin-1 therapy in severe hidradenitis suppurativa: a case report.抗白细胞介素-1 治疗在严重化脓性汗腺炎中的失败:一例报告。
一种新型非药物痤疮疗法的疗效:芦荟凝胶联合超声及软膜治疗轻至重度面部痤疮
Front Med (Lausanne). 2021 May 21;8:662640. doi: 10.3389/fmed.2021.662640. eCollection 2021.
4
Acute form of acne inversa in an 18-week pregnant patient: a case study.一名18周妊娠患者的急性化脓性汗腺炎:病例报告
Postepy Dermatol Alergol. 2019 Apr;36(2):242-246. doi: 10.5114/ada.2018.79472. Epub 2019 May 14.
5
A cross-sectional epidemiological study of hidradenitis suppurativa in an Irish population (SHIP).爱尔兰人群中化脓性汗腺炎的横断面流行病学研究(SHIP)。
J Eur Acad Dermatol Venereol. 2018 Mar;32(3):467-473. doi: 10.1111/jdv.14686. Epub 2017 Dec 6.
6
Synchronizing Pharmacotherapy in Acne with Review of Clinical Care.痤疮药物治疗与临床护理评估的同步性
Indian J Dermatol. 2017 Jul-Aug;62(4):341-357. doi: 10.4103/ijd.IJD_41_17.
Dermatology. 2013;226(2):97-100. doi: 10.1159/000343221. Epub 2013 May 25.
4
Impact of TNF-α antagonists on the quality of life in selected skin diseases.TNF-α 拮抗剂对选定皮肤病患者生活质量的影响。
G Ital Dermatol Venereol. 2013 Jun;148(3):243-8.
5
Disparate results in studies of adalimumab in the treatment of hidradenitis suppurativa: comment on the article by Amano et al.阿达木单抗治疗化脓性汗腺炎研究结果不一:对天野等人文章的评论
Int J Dermatol. 2013 Mar;52(3):380-1. doi: 10.1111/j.1365-4632.2011.04949.x.
6
Adalimumab for the treatment of moderate to severe Hidradenitis suppurativa: a parallel randomized trial.阿达木单抗治疗中重度化脓性汗腺炎的平行随机试验。
Ann Intern Med. 2012 Dec 18;157(12):846-55. doi: 10.7326/0003-4819-157-12-201212180-00004.
7
Systemic therapy with immunosuppressive agents and retinoids in hidradenitis suppurativa: a systematic review.系统治疗法用免疫抑制剂和类视黄醇在化脓性汗腺炎中:系统评价。
Br J Dermatol. 2013 Feb;168(2):243-52. doi: 10.1111/bjd.12104.
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A prospective open-label clinical trial of efficacy of the every week administration of adalimumab in the treatment of hidradenitis suppurativa.一项关于每周使用阿达木单抗治疗化脓性汗腺炎疗效的前瞻性开放标签临床试验。
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The off-label treatment of severe hidradenitis suppurativa with TNF-α inhibitors: a systematic review.TNF-α 抑制剂治疗重度化脓性汗腺炎的超适应证治疗:系统评价。
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