Trauninger Anita, Pfund Zoltán, Koszegi Tamás, Czopf József
Department of Neurology, Medical Faculty, University of Pécs, Hungary.
Headache. 2002 Feb;42(2):114-9. doi: 10.1046/j.1526-4610.2002.02026.x.
To determine whether migraineurs may have a systemic deficiency of magnesium.
Magnesium deficiency has been shown to play a potential role in the pathogenesis of migraine, but there are no data on total body magnesium status in migraineurs.
An oral magnesium load test was performed by giving 3000 mg of magnesium lactate during a 24-hour interictal period to 20 patients with migraine (15 women and 5 men; mean age, 37.9 years) and 20 healthy volunteers (16 women and 4 men; mean age, 39.6 years). Baseline and postload magnesium concentrations were determined from serum and 24-hour urine specimens.
There was no significant difference between the groups in the baseline serum and urine magnesium concentrations, although the latter tended to be lower (P = .064) in the migraine group. The postload magnesium concentrations were significantly higher within both the migraine (P < .0001 and P < .0001) and the control (P = .0009 and P < .0001) groups compared to the baseline values. After loading, the 24-hour urinary magnesium excretions were significantly lower (P = .0007) in the patients with migraine than in the controls, but serum values did not differ.
Magnesium retention occurs in patients with migraine after oral loading, suggesting a systemic magnesium deficiency.
确定偏头痛患者是否存在全身性镁缺乏。
镁缺乏已被证明在偏头痛的发病机制中可能起作用，但尚无关于偏头痛患者全身镁状态的数据。
在24小时的发作间期，对20例偏头痛患者（15名女性和5名男性；平均年龄37.9岁）和20名健康志愿者（16名女性和4名男性；平均年龄39.6岁）口服3000毫克乳酸镁进行口服镁负荷试验。从血清和24小时尿液标本中测定基线和负荷后镁浓度。
两组的基线血清和尿镁浓度无显著差异，尽管偏头痛组的尿镁浓度往往较低（P = 0.064）。与基线值相比，偏头痛组（P < 0.0001和P < 0.0001）和对照组（P = 0.0009和P < 0.0001）的负荷后镁浓度均显著升高。负荷后，偏头痛患者的24小时尿镁排泄量显著低于对照组（P = 0.0007），但血清值无差异。
偏头痛患者口服负荷后会出现镁潴留，提示全身性镁缺乏。
