Cleare Anthony J, Reid Steven, Chalder Trudie, Hotopf Matthew, Wessely Simon
King's College London, Institute of Psychiatry, Psychology and Neuroscience, Centre for Affective Disorders, Department of Psychological Medicine, London, UK.
BMJ Clin Evid. 2015 Sep 28;2015:1101.
Chronic fatigue syndrome affects between 0.006% and 3% of the population depending on the criteria of definition used, with women being at higher risk than men.
We conducted a systematic overview, aiming to answer the following clinical question: What are the effects of selected treatments for chronic fatigue syndrome? We searched: Medline, Embase, The Cochrane Library, and other important databases up to November 2013 (Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review).
At this update, searching of electronic databases retrieved 169 studies. After deduplication and removal of conference abstracts, 86 records were screened for inclusion in the overview. Appraisal of titles and abstracts led to the exclusion of 71 studies and the further review of 15 full publications. Of the 15 full articles evaluated, two systematic reviews, one RCT, and one further follow-up report of an RCT were added at this update. We performed a GRADE evaluation for 23 PICO combinations.
In this systematic overview, we categorised the effectiveness of four interventions based on information relating to the effectiveness and safety of antidepressants, cognitive behavioural therapy, corticosteroids, and graded exercise therapy.
根据所采用的定义标准，慢性疲劳综合征在0.006%至3%的人群中存在，女性患病风险高于男性。
我们进行了一项系统综述，旨在回答以下临床问题：慢性疲劳综合征的选定治疗方法有哪些效果？我们检索了：截至2013年11月的Medline、Embase、Cochrane图书馆及其他重要数据库（临床证据综述会定期更新；请查看我们的网站获取本综述的最新版本）。
在本次更新时，检索电子数据库共获得169项研究。经过去重和剔除会议摘要后，筛选出86条记录以纳入综述。对标题和摘要的评估导致排除71项研究，并对15篇全文出版物进行进一步审查。在本次更新时，对所评估的15篇全文文章中，增加了两项系统综述、一项随机对照试验以及一项随机对照试验的进一步随访报告。我们对23种PICO组合进行了GRADE评估。
在本系统综述中，我们根据与抗抑郁药、认知行为疗法、皮质类固醇和分级运动疗法的有效性和安全性相关的信息，对四种干预措施的有效性进行了分类。
