Institute of Materials Research and Engineering, A*STAR (Agency for Science, Technology and Research), 3 Research Link, Singapore 117602.
Biomater Sci. 2015 Dec;3(12):1505-18. doi: 10.1039/c5bm00307e. Epub 2015 Sep 29.
The adhesion and proliferation of bacteria on various artificial surfaces affects the functionality of these specific interfaces. To overcome the problems caused by bacterial growth on these surfaces, various antibacterial coatings were developed. In this review, we summarized most of the antibacterial surfaces prepared by the Layer-by-Layer (LbL) assembly approach and classified these LbL films based on their antibacterial mechanisms. In the first group, the bactericidal LbL assemblies which incorporate various biocides including heavy metals, antibiotics, cationic molecules, antimicrobial peptides and enzymes are able to kill surrounding or contacted bacteria. In the second group, we focused on the physical aspects of film surfaces. Bacterial adhesion resistant LbL films have been fabricated to adjust the substrate surface properties such as surface free energy (or wettability), roughness, and surface charge which may affect the adhesion of bacteria. Furthermore, as an enhancement in the antibacterial efficiency, multifunctional LbL assemblies combining both bactericidal and adhesion resistant functionalities were discussed. The advantages and limitations of these antibacterial LbL assemblies were summarized and subsequently directions for future development were proposed.
各种人工表面上细菌的黏附和增殖会影响这些特定界面的功能。为了克服这些表面上细菌生长带来的问题，人们开发了各种抗菌涂层。在这篇综述中，我们总结了通过层层（LbL）组装方法制备的大多数抗菌表面，并根据其抗菌机制对这些 LbL 薄膜进行了分类。在第一组中，包含各种杀生物剂的杀菌 LbL 组装体，包括重金属、抗生素、阳离子分子、抗菌肽和酶，能够杀死周围或接触到的细菌。在第二组中，我们专注于薄膜表面的物理方面。已经制备了抗细菌黏附的 LbL 薄膜，以调节基底表面性质，如表面自由能（或润湿性）、粗糙度和表面电荷，这些性质可能会影响细菌的黏附。此外，作为提高抗菌效率的一种手段，还讨论了结合杀菌和抗黏附功能的多功能 LbL 组装体。总结了这些抗菌 LbL 组装体的优点和局限性，并提出了未来发展的方向。
