推动基于人类胚胎干细胞的再生医学疗法走向临床应用。
Progressing a human embryonic stem-cell-based regenerative medicine therapy towards the clinic.
作者信息
Whiting Paul, Kerby Julie, Coffey Peter, da Cruz Lyndon, McKernan Ruth
机构信息
Pfizer Neusentis, Granta Park, Cambridge CB21 6GS, UK
Pfizer Neusentis, Granta Park, Cambridge CB21 6GS, UK.
出版信息
Philos Trans R Soc Lond B Biol Sci. 2015 Oct 19;370(1680):20140375. doi: 10.1098/rstb.2014.0375.
Abstract
Since the first publication of the derivation of human embryonic stem cells in 1998, there has been hope and expectation that this technology will lead to a wave of regenerative medicine therapies with the potential to revolutionize our approach to managing certain diseases. Despite significant resources in this direction, the path to the clinic for an embryonic stem-cell-based regenerative medicine therapy has not proven straightforward, though in the past few years progress has been made. Here, with a focus upon retinal disease, we discuss the current status of the development of such therapies. We also highlight some of our own experiences of progressing a retinal pigment epithelium cell replacement therapy towards the clinic.
摘要
自1998年首次发表关于人类胚胎干细胞的推导以来，人们一直希望并期待这项技术将引发一波再生医学疗法，有可能彻底改变我们治疗某些疾病的方法。尽管在这个方向上投入了大量资源，但基于胚胎干细胞的再生医学疗法通往临床的道路并不简单，不过在过去几年里已经取得了进展。在此，我们聚焦于视网膜疾病，讨论此类疗法的当前发展状况。我们还强调了我们自己在将视网膜色素上皮细胞替代疗法推进到临床阶段过程中的一些经历。
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