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纳米颗粒介导的肿瘤血管破坏：放射治疗中的一种新策略。

Nanoparticle Mediated Tumor Vascular Disruption: A Novel Strategy in Radiation Therapy.

作者信息

Kunjachan Sijumon, Detappe Alexandre, Kumar Rajiv, Ireland Thomas, Cameron Lisa, Biancur Douglas E, Motto-Ros Vincent, Sancey Lucie, Sridhar Srinivas, Makrigiorgos G Mike, Berbeco Ross I

机构信息

Department of Radiation Oncology, Brigham and Women's Hospital , Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, United States.

Institut Lumière Matière, Université Claude Bernard Lyon1-CNRS, Université de Lyon , 69007 Lyon, France.

出版信息

Nano Lett. 2015 Nov 11;15(11):7488-96. doi: 10.1021/acs.nanolett.5b03073. Epub 2015 Oct 6.

DOI:10.1021/acs.nanolett.5b03073
PMID:26418302
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5507193/
Abstract

More than 50% of all cancer patients receive radiation therapy. The clinical delivery of curative radiation dose is strictly restricted by the proximal healthy tissues. We propose a dual-targeting strategy using vessel-targeted-radiosensitizing gold nanoparticles and conformal-image guided radiation therapy to specifically amplify damage in the tumor neoendothelium. The resulting tumor vascular disruption substantially improved the therapeutic outcome and subsidized the radiation/nanoparticle toxicity, extending its utility to intransigent or nonresectable tumors that barely respond to standard therapies.

摘要

超过50%的癌症患者接受放射治疗。根治性放射剂量的临床递送受到近端健康组织的严格限制。我们提出了一种双靶向策略，使用血管靶向放射增敏金纳米颗粒和适形图像引导放射治疗，以特异性放大肿瘤新生内皮中的损伤。由此产生的肿瘤血管破坏显著改善了治疗效果，并减轻了放射/纳米颗粒毒性，将其应用扩展到对标准疗法几乎没有反应的难治性或不可切除肿瘤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f915/5507193/4f3ad8bfe186/nihms874112f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f915/5507193/482ca9bf37e6/nihms874112f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f915/5507193/e85670889c45/nihms874112f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f915/5507193/e985d0e077fe/nihms874112f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f915/5507193/2cbf33d0b262/nihms874112f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f915/5507193/f915ec001a7d/nihms874112f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f915/5507193/7bc9687aaae3/nihms874112f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f915/5507193/4f3ad8bfe186/nihms874112f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f915/5507193/482ca9bf37e6/nihms874112f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f915/5507193/e85670889c45/nihms874112f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f915/5507193/e985d0e077fe/nihms874112f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f915/5507193/2cbf33d0b262/nihms874112f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f915/5507193/f915ec001a7d/nihms874112f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f915/5507193/7bc9687aaae3/nihms874112f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f915/5507193/4f3ad8bfe186/nihms874112f7.jpg

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3
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4
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