纳米颗粒介导的肿瘤血管破坏：放射治疗中的一种新策略。
Nanoparticle Mediated Tumor Vascular Disruption: A Novel Strategy in Radiation Therapy.
作者信息
Kunjachan Sijumon, Detappe Alexandre, Kumar Rajiv, Ireland Thomas, Cameron Lisa, Biancur Douglas E, Motto-Ros Vincent, Sancey Lucie, Sridhar Srinivas, Makrigiorgos G Mike, Berbeco Ross I
机构信息
Department of Radiation Oncology, Brigham and Women's Hospital , Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, United States.
Institut Lumière Matière, Université Claude Bernard Lyon1-CNRS, Université de Lyon , 69007 Lyon, France.
出版信息
Nano Lett. 2015 Nov 11;15(11):7488-96. doi: 10.1021/acs.nanolett.5b03073. Epub 2015 Oct 6.
Abstract
More than 50% of all cancer patients receive radiation therapy. The clinical delivery of curative radiation dose is strictly restricted by the proximal healthy tissues. We propose a dual-targeting strategy using vessel-targeted-radiosensitizing gold nanoparticles and conformal-image guided radiation therapy to specifically amplify damage in the tumor neoendothelium. The resulting tumor vascular disruption substantially improved the therapeutic outcome and subsidized the radiation/nanoparticle toxicity, extending its utility to intransigent or nonresectable tumors that barely respond to standard therapies.
摘要
超过50%的癌症患者接受放射治疗。根治性放射剂量的临床递送受到近端健康组织的严格限制。我们提出了一种双靶向策略，使用血管靶向放射增敏金纳米颗粒和适形图像引导放射治疗，以特异性放大肿瘤新生内皮中的损伤。由此产生的肿瘤血管破坏显著改善了治疗效果，并减轻了放射/纳米颗粒毒性，将其应用扩展到对标准疗法几乎没有反应的难治性或不可切除肿瘤。
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本文引用的文献
1
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ACS Nano. 2015 Aug 25;9(8):7925-39. doi: 10.1021/acsnano.5b00042. Epub 2015 Jul 21.
2
Noninvasive Imaging of Nanomedicines and Nanotheranostics: Principles, Progress, and Prospects.纳米药物与纳米诊疗剂的无创成像：原理、进展与展望
Chem Rev. 2015 Oct 14;115(19):10907-37. doi: 10.1021/cr500314d. Epub 2015 Jul 13.
3
Long-term in vivo clearance of gadolinium-based AGuIX nanoparticles and their biocompatibility after systemic injection.经系统注射后，基于钆的 AGuIX 纳米颗粒的体内长期清除及其生物相容性。
ACS Nano. 2015 Mar 24;9(3):2477-88. doi: 10.1021/acsnano.5b00552. Epub 2015 Feb 26.
4
Cancer statistics, 2015.癌症统计数据，2015 年。
CA Cancer J Clin. 2015 Jan-Feb;65(1):5-29. doi: 10.3322/caac.21254. Epub 2015 Jan 5.
5
Image-guided radiotherapy platform using single nodule conditional lung cancer mouse models.使用单结节条件性肺癌小鼠模型的图像引导放射治疗平台。
Nat Commun. 2014 Dec 18;5:5870. doi: 10.1038/ncomms6870.
6
Gold nanoparticles in radiation research: potential applications for imaging and radiosensitization.辐射研究中的金纳米颗粒：成像和放射增敏的潜在应用。
Transl Cancer Res. 2013 Aug 1;2(4):280-291. doi: 10.3978/j.issn.2218-676X.2013.08.09.
7
Laser spectrometry for multi-elemental imaging of biological tissues.用于生物组织多元素成像的激光光谱法。
Sci Rep. 2014 Aug 14;4:6065. doi: 10.1038/srep06065.
8
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Clin Oncol (R Coll Radiol). 2014 Dec;26(12):757-61. doi: 10.1016/j.clon.2014.08.007. Epub 2014 Sep 3.
9
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Nanoscale. 2014 Oct 21;6(20):12026-33. doi: 10.1039/c4nr02535k.
10
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