Ego A, Prunet C, Lebreton E, Blondel B, Kaminski M, Goffinet F, Zeitlin J
Inserm UMR 1153, équipe de recherche en épidémiologie obstétricale, périnatale et pédiatrique (EPOPé), centre de recherche épidémiologie et statistique Sorbonne Paris-Cité, DHU risques et grossesse, université Paris-Descartes, 75014 Paris, France; Pôle santé publique, CHU de Grenoble, 38000 Grenoble, France.
Inserm UMR 1153, équipe de recherche en épidémiologie obstétricale, périnatale et pédiatrique (EPOPé), centre de recherche épidémiologie et statistique Sorbonne Paris-Cité, DHU risques et grossesse, université Paris-Descartes, 75014 Paris, France.
J Gynecol Obstet Biol Reprod (Paris). 2016 Feb;45(2):155-64. doi: 10.1016/j.jgyn.2015.08.009. Epub 2015 Sep 28.
We developed intrauterine growth references, called EPOPé curves, in line with recommendations for screening of intra-uterine growth restriction issued in 2013 by the French College of Obstetricians and Gynecologists.
Using the French Perinatal Survey (FPS) 2010, we adapted the methodology developed by Gardosi (1) to model intrauterine growth and its distribution and (2) to adjust for physiological fetal and maternal factors influencing fetal weight. Based on this model, 3 reference curves (unadjusted, adjusted for fetal sex, and adjusted for fetal sex, and maternal height, weight and parity) were proposed. We applied these models to births in the 2010 FPS and the French hospital discharge database (PMSI) in 2011-2012.
Among singleton live births in the FPS and the PMSI, the model adjusted for fetal sex identified 3.2 and 3.3% of births below the 3rd centile respectively, and 10.0 and 10.2% below the 10th. In model adjusted for maternal factors, 4.0% of births from the FPS 2010 were reclassified, but population rates remained at 3.0 and 10.0%.
This growth model is appropriate for French births, and allows for the implementation of a homogeneous definition of small for gestational age infants during pregnancy and at birth.
我们根据法国妇产科医师学会2013年发布的关于筛查宫内生长受限的建议，制定了宫内生长参考曲线，即EPOPé曲线。
利用2010年法国围产期调查（FPS），我们采用了加尔多维（1）开发的方法，（1）对宫内生长及其分布进行建模，（2）对影响胎儿体重的生理胎儿和母亲因素进行调整。基于该模型，提出了3条参考曲线（未调整、按胎儿性别调整、按胎儿性别、母亲身高、体重和产次调整）。我们将这些模型应用于2010年FPS的出生数据以及2011 - 2012年法国医院出院数据库（PMSI）。
在FPS和PMSI的单胎活产中，按胎儿性别调整的模型分别识别出3.2%和3.3%的出生体重低于第3百分位数，10.0%和10.2%低于第10百分位数。在按母亲因素调整的模型中，2010年FPS中有4.0%的出生情况被重新分类，但总体比例仍为3.0%和10.0%。
这种生长模型适用于法国的出生情况，并允许在孕期和出生时对小于胎龄儿实施统一的定义。
